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Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

AIM: The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D. METHODS: Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D...

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Autores principales: Pessoa Mamede, Laine de Carvalho Guerra, de Lima, Rafaela Lira Formiga Cavalcanti, Silva, Alexandre Sérgio, Rodrigues Pita, João Carlos Lima, Galdino Gomes, Nadjeanny Ingrid, de Sena, Elisama Araújo, Moraes Nobrega, Rhayra Priscila, Scarano Alcântara, João Otávio, Fontes de Souza, Julie Hanna, Cardoso, Glêbia Alexa, de Brito Alves, José Luiz, Rodrigues Gonçalves, Maria da Conceição
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871878/
https://www.ncbi.nlm.nih.gov/pubmed/33574687
http://dx.doi.org/10.2147/DMSO.S285597
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author Pessoa Mamede, Laine de Carvalho Guerra
de Lima, Rafaela Lira Formiga Cavalcanti
Silva, Alexandre Sérgio
Rodrigues Pita, João Carlos Lima
Galdino Gomes, Nadjeanny Ingrid
de Sena, Elisama Araújo
Moraes Nobrega, Rhayra Priscila
Scarano Alcântara, João Otávio
Fontes de Souza, Julie Hanna
Cardoso, Glêbia Alexa
de Brito Alves, José Luiz
Rodrigues Gonçalves, Maria da Conceição
author_facet Pessoa Mamede, Laine de Carvalho Guerra
de Lima, Rafaela Lira Formiga Cavalcanti
Silva, Alexandre Sérgio
Rodrigues Pita, João Carlos Lima
Galdino Gomes, Nadjeanny Ingrid
de Sena, Elisama Araújo
Moraes Nobrega, Rhayra Priscila
Scarano Alcântara, João Otávio
Fontes de Souza, Julie Hanna
Cardoso, Glêbia Alexa
de Brito Alves, José Luiz
Rodrigues Gonçalves, Maria da Conceição
author_sort Pessoa Mamede, Laine de Carvalho Guerra
collection PubMed
description AIM: The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D. METHODS: Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention. RESULTS: Anthropometric variables (waist circumference, waist–hip ratio, waist–height ratio and body mass index) were similar between groups (p > 0.05). VD3 supplementation increased the serum levels of 25-hydroxyvitamin D (p=0.000), malondialdehyde (p=0.021) and C-reactive protein (p=0.043) in overweight and obese women. Additionally, VD3 supplementation reduced the serum levels of aspartate aminotransferase (AST, p=0.035), alanine aminotransferase (ALT, p<0.0001) in overweight and obese women. Despite this, the serum levels of parathyroid hormone (PTH), fasting glucose (FG), and alpha-1- acid glycoprotein (A1GPA), total antioxidant capacity (TAC) were similar between groups. CONCLUSION: In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers.
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spelling pubmed-78718782021-02-10 Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Pessoa Mamede, Laine de Carvalho Guerra de Lima, Rafaela Lira Formiga Cavalcanti Silva, Alexandre Sérgio Rodrigues Pita, João Carlos Lima Galdino Gomes, Nadjeanny Ingrid de Sena, Elisama Araújo Moraes Nobrega, Rhayra Priscila Scarano Alcântara, João Otávio Fontes de Souza, Julie Hanna Cardoso, Glêbia Alexa de Brito Alves, José Luiz Rodrigues Gonçalves, Maria da Conceição Diabetes Metab Syndr Obes Clinical Trial Report AIM: The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D. METHODS: Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention. RESULTS: Anthropometric variables (waist circumference, waist–hip ratio, waist–height ratio and body mass index) were similar between groups (p > 0.05). VD3 supplementation increased the serum levels of 25-hydroxyvitamin D (p=0.000), malondialdehyde (p=0.021) and C-reactive protein (p=0.043) in overweight and obese women. Additionally, VD3 supplementation reduced the serum levels of aspartate aminotransferase (AST, p=0.035), alanine aminotransferase (ALT, p<0.0001) in overweight and obese women. Despite this, the serum levels of parathyroid hormone (PTH), fasting glucose (FG), and alpha-1- acid glycoprotein (A1GPA), total antioxidant capacity (TAC) were similar between groups. CONCLUSION: In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers. Dove 2021-02-04 /pmc/articles/PMC7871878/ /pubmed/33574687 http://dx.doi.org/10.2147/DMSO.S285597 Text en © 2021 Pessoa Mamede et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Clinical Trial Report
Pessoa Mamede, Laine de Carvalho Guerra
de Lima, Rafaela Lira Formiga Cavalcanti
Silva, Alexandre Sérgio
Rodrigues Pita, João Carlos Lima
Galdino Gomes, Nadjeanny Ingrid
de Sena, Elisama Araújo
Moraes Nobrega, Rhayra Priscila
Scarano Alcântara, João Otávio
Fontes de Souza, Julie Hanna
Cardoso, Glêbia Alexa
de Brito Alves, José Luiz
Rodrigues Gonçalves, Maria da Conceição
Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_full Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_fullStr Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_full_unstemmed Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_short Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
title_sort effects of a single oral megadose of vitamin d3 on inflammation and oxidative stress markers in overweight and obese women: a randomized, double-blind, placebo-controlled clinical trial
topic Clinical Trial Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871878/
https://www.ncbi.nlm.nih.gov/pubmed/33574687
http://dx.doi.org/10.2147/DMSO.S285597
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