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Viral gene delivery vectors: the next generation medicines for immune-related diseases
Viruses have evolved to efficiently express their genes in host cells, which makes them ideally suited as gene delivery vectors for gene and immunotherapies. Replication competent (RC) viral vectors encoding foreign or self-proteins induce strong T-cell responses that can be used for the development...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872028/ https://www.ncbi.nlm.nih.gov/pubmed/32412865 http://dx.doi.org/10.1080/21645515.2020.1757989 |
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author | De Haan, Peter Van Diemen, Ferdy R. Toscano, Miguel G. |
author_facet | De Haan, Peter Van Diemen, Ferdy R. Toscano, Miguel G. |
author_sort | De Haan, Peter |
collection | PubMed |
description | Viruses have evolved to efficiently express their genes in host cells, which makes them ideally suited as gene delivery vectors for gene and immunotherapies. Replication competent (RC) viral vectors encoding foreign or self-proteins induce strong T-cell responses that can be used for the development of effective cancer treatments. Replication-defective (RD) viral vectors encoding self-proteins are non-immunogenic when introduced in a host naïve for the cognate virus. RD viral vectors can be used to develop gene replacement therapies for genetic disorders and tolerization therapies for autoimmune diseases and allergies. Degenerative/inflammatory diseases are associated with chronic inflammation and immune responses that damage the tissues involved. These diseases therefore strongly resemble autoimmune diseases. This review deals with the use of RC and RD viral vectors for unraveling the pathogenesis of immune-related diseases and their application to the development of the next generation prophylactics and therapeutics for todays’ major diseases. |
format | Online Article Text |
id | pubmed-7872028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-78720282021-02-26 Viral gene delivery vectors: the next generation medicines for immune-related diseases De Haan, Peter Van Diemen, Ferdy R. Toscano, Miguel G. Hum Vaccin Immunother Review Viruses have evolved to efficiently express their genes in host cells, which makes them ideally suited as gene delivery vectors for gene and immunotherapies. Replication competent (RC) viral vectors encoding foreign or self-proteins induce strong T-cell responses that can be used for the development of effective cancer treatments. Replication-defective (RD) viral vectors encoding self-proteins are non-immunogenic when introduced in a host naïve for the cognate virus. RD viral vectors can be used to develop gene replacement therapies for genetic disorders and tolerization therapies for autoimmune diseases and allergies. Degenerative/inflammatory diseases are associated with chronic inflammation and immune responses that damage the tissues involved. These diseases therefore strongly resemble autoimmune diseases. This review deals with the use of RC and RD viral vectors for unraveling the pathogenesis of immune-related diseases and their application to the development of the next generation prophylactics and therapeutics for todays’ major diseases. Taylor & Francis 2020-05-15 /pmc/articles/PMC7872028/ /pubmed/32412865 http://dx.doi.org/10.1080/21645515.2020.1757989 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review De Haan, Peter Van Diemen, Ferdy R. Toscano, Miguel G. Viral gene delivery vectors: the next generation medicines for immune-related diseases |
title | Viral gene delivery vectors: the next generation medicines for immune-related diseases |
title_full | Viral gene delivery vectors: the next generation medicines for immune-related diseases |
title_fullStr | Viral gene delivery vectors: the next generation medicines for immune-related diseases |
title_full_unstemmed | Viral gene delivery vectors: the next generation medicines for immune-related diseases |
title_short | Viral gene delivery vectors: the next generation medicines for immune-related diseases |
title_sort | viral gene delivery vectors: the next generation medicines for immune-related diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872028/ https://www.ncbi.nlm.nih.gov/pubmed/32412865 http://dx.doi.org/10.1080/21645515.2020.1757989 |
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