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GSK2593074A blocks progression of existing abdominal aortic dilation

OBJECTIVE: Receptor interacting proteins kinase 1 and 3 (RIPK1 and RIPK3) have been shown to play essential roles in the pathogenesis of abdominal aortic aneurysms (AAAs) by mediating necroptosis and inflammation. We previously discovered a small molecular inhibitor GSK2593074A (GSK’074) that binds...

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Detalles Bibliográficos
Autores principales:	Khoury, Mitri K., Zhou, Ting, Yang, Huan, Prince, Samantha R., Gupta, Kartik, Stranz, Amelia R., Wang, Qiwei, Liu, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Basic Reserch Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872141/ https://www.ncbi.nlm.nih.gov/pubmed/33569546 http://dx.doi.org/10.1016/j.jvssci.2020.07.001

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