Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

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The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contributes to elements of viral tropism and pathogenesis, antiviral immunity, and treatment response to...

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Detalles Bibliográficos
Autores principales: Fiege, Jessica K., Thiede, Joshua M., Nanda, Hezkiel Arya, Matchett, William E., Moore, Patrick J., Montanari, Noe Rico, Thielen, Beth K., Daniel, Jerry, Stanley, Emma, Hunter, Ryan C., Menachery, Vineet D., Shen, Steven S., Bold, Tyler D., Langlois, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872261/
https://www.ncbi.nlm.nih.gov/pubmed/33507952
http://dx.doi.org/10.1371/journal.ppat.1009292

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