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Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study

BACKGROUND: Insomnia may be a risk factor for cardiovascular disease in HIV (HIV-CVD); however, mechanisms have yet to be elucidated. METHODS: We examined cross-sectional associations of insomnia symptoms with biological mechanisms of HIV-CVD (immune activation, systemic inflammation, and coagulatio...

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Autores principales: Polanka, Brittanny M., Kundu, Suman, So-Armah, Kaku A., Freiberg, Matthew S., Gupta, Samir K., Zapolski, Tamika C. B., Hirsh, Adam T., Bedimo, Roger J., Budoff, Matthew J., Butt, Adeel A., Chang, Chung-Chou H., Gottlieb, Stephen S., Marconi, Vincent C., Womack, Julie A., Stewart, Jesse C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872271/
https://www.ncbi.nlm.nih.gov/pubmed/33561176
http://dx.doi.org/10.1371/journal.pone.0246073
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author Polanka, Brittanny M.
Kundu, Suman
So-Armah, Kaku A.
Freiberg, Matthew S.
Gupta, Samir K.
Zapolski, Tamika C. B.
Hirsh, Adam T.
Bedimo, Roger J.
Budoff, Matthew J.
Butt, Adeel A.
Chang, Chung-Chou H.
Gottlieb, Stephen S.
Marconi, Vincent C.
Womack, Julie A.
Stewart, Jesse C.
author_facet Polanka, Brittanny M.
Kundu, Suman
So-Armah, Kaku A.
Freiberg, Matthew S.
Gupta, Samir K.
Zapolski, Tamika C. B.
Hirsh, Adam T.
Bedimo, Roger J.
Budoff, Matthew J.
Butt, Adeel A.
Chang, Chung-Chou H.
Gottlieb, Stephen S.
Marconi, Vincent C.
Womack, Julie A.
Stewart, Jesse C.
author_sort Polanka, Brittanny M.
collection PubMed
description BACKGROUND: Insomnia may be a risk factor for cardiovascular disease in HIV (HIV-CVD); however, mechanisms have yet to be elucidated. METHODS: We examined cross-sectional associations of insomnia symptoms with biological mechanisms of HIV-CVD (immune activation, systemic inflammation, and coagulation) among 1,542 people with HIV from the Veterans Aging Cohort Study (VACS) Biomarker Cohort. Past-month insomnia symptoms were assessed by the item, “Difficulty falling or staying asleep?,” with the following response options: “I do not have this symptom” or “I have this symptom and…” “it doesn’t bother me,” “it bothers me a little,” “it bothers me,” “it bothers me a lot.” Circulating levels of the monocyte activation marker soluble CD14 (sCD14), inflammatory marker interleukin-6 (IL-6), and coagulation marker D-dimer were determined from blood specimens. Demographic- and fully-adjusted (CVD risk factors, potential confounders, HIV-related factors) regression models were constructed, with log-transformed biomarker variables as the outcomes. We present the exponentiated regression coefficient (exp[b]) and its 95% confidence interval (CI). RESULTS: We observed no significant associations between insomnia symptoms and sCD14 or IL-6. For D-dimer, veterans in the “Bothers a Lot” group had, on average, 17% higher D-dimer than veterans in the “No Difficulty Falling or Staying Asleep” group in the demographic-adjusted model (exp[b] = 1.17, 95%CI = 1.01–1.37, p = .04). This association was nonsignificant in the fully-adjusted model (exp[b] = 1.09, 95%CI = 0.94–1.26, p = .27). CONCLUSION: We observed little evidence of relationships between insomnia symptoms and markers of biological mechanisms of HIV-CVD. Other mechanisms may be responsible for the insomnia-CVD relationship in HIV; however, future studies with comprehensive assessments of insomnia symptoms are warranted.
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spelling pubmed-78722712021-02-19 Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study Polanka, Brittanny M. Kundu, Suman So-Armah, Kaku A. Freiberg, Matthew S. Gupta, Samir K. Zapolski, Tamika C. B. Hirsh, Adam T. Bedimo, Roger J. Budoff, Matthew J. Butt, Adeel A. Chang, Chung-Chou H. Gottlieb, Stephen S. Marconi, Vincent C. Womack, Julie A. Stewart, Jesse C. PLoS One Research Article BACKGROUND: Insomnia may be a risk factor for cardiovascular disease in HIV (HIV-CVD); however, mechanisms have yet to be elucidated. METHODS: We examined cross-sectional associations of insomnia symptoms with biological mechanisms of HIV-CVD (immune activation, systemic inflammation, and coagulation) among 1,542 people with HIV from the Veterans Aging Cohort Study (VACS) Biomarker Cohort. Past-month insomnia symptoms were assessed by the item, “Difficulty falling or staying asleep?,” with the following response options: “I do not have this symptom” or “I have this symptom and…” “it doesn’t bother me,” “it bothers me a little,” “it bothers me,” “it bothers me a lot.” Circulating levels of the monocyte activation marker soluble CD14 (sCD14), inflammatory marker interleukin-6 (IL-6), and coagulation marker D-dimer were determined from blood specimens. Demographic- and fully-adjusted (CVD risk factors, potential confounders, HIV-related factors) regression models were constructed, with log-transformed biomarker variables as the outcomes. We present the exponentiated regression coefficient (exp[b]) and its 95% confidence interval (CI). RESULTS: We observed no significant associations between insomnia symptoms and sCD14 or IL-6. For D-dimer, veterans in the “Bothers a Lot” group had, on average, 17% higher D-dimer than veterans in the “No Difficulty Falling or Staying Asleep” group in the demographic-adjusted model (exp[b] = 1.17, 95%CI = 1.01–1.37, p = .04). This association was nonsignificant in the fully-adjusted model (exp[b] = 1.09, 95%CI = 0.94–1.26, p = .27). CONCLUSION: We observed little evidence of relationships between insomnia symptoms and markers of biological mechanisms of HIV-CVD. Other mechanisms may be responsible for the insomnia-CVD relationship in HIV; however, future studies with comprehensive assessments of insomnia symptoms are warranted. Public Library of Science 2021-02-09 /pmc/articles/PMC7872271/ /pubmed/33561176 http://dx.doi.org/10.1371/journal.pone.0246073 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Polanka, Brittanny M.
Kundu, Suman
So-Armah, Kaku A.
Freiberg, Matthew S.
Gupta, Samir K.
Zapolski, Tamika C. B.
Hirsh, Adam T.
Bedimo, Roger J.
Budoff, Matthew J.
Butt, Adeel A.
Chang, Chung-Chou H.
Gottlieb, Stephen S.
Marconi, Vincent C.
Womack, Julie A.
Stewart, Jesse C.
Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
title Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
title_full Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
title_fullStr Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
title_full_unstemmed Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
title_short Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
title_sort insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in hiv: veterans aging cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872271/
https://www.ncbi.nlm.nih.gov/pubmed/33561176
http://dx.doi.org/10.1371/journal.pone.0246073
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