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Kaposi’s sarcoma-associated herpesvirus processivity factor (PF-8) recruits cellular E3 ubiquitin ligase CHFR to promote PARP1 degradation and lytic replication

Kaposi’s sarcoma–associated herpesvirus (KSHV), which belongs to the gammaherpesvirus subfamily, is associated with the pathogenesis of various tumors. Nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP1) catalyzes the polymerization of ADP-ribose units on target proteins. In KSHV-infected cells, PA...

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Detalles Bibliográficos
Autores principales:	Chung, Woo-Chang, Lee, Seungrae, Kim, Yejin, Seo, Jong Bok, Song, Moon Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872283/ https://www.ncbi.nlm.nih.gov/pubmed/33508027 http://dx.doi.org/10.1371/journal.ppat.1009261

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