Sex disparities and neutralizing antibody durability to SARS-CoV-2 infection in convalescent individuals

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has now caused over 2 million deaths worldwide and continues to expand. Currently, much is unknown about functionally neutralizing human antibody responses and durability...

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Detalles Bibliográficos
Autores principales: Markmann, Alena J., Giallourou, Natasa, Bhowmik, D. Ryan, Hou, Yixuan J., Lerner, Aaron, Martinez, David R., Premkumar, Lakshmanane, Root, Heather, van Duin, David, Napravnik, Sonia, Graham, Stephen D., Guerra, Quique, Raut, Rajendra, Petropoulos, Christos J., Wrin, Terri, Cornaby, Caleb, Schmitz, John, Kuruc, JoAnn, Weiss, Susan, Park, Yara, Baric, Ralph, de Silva, Aravinda M., Margolis, David M., Bartelt, Luther A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872367/
https://www.ncbi.nlm.nih.gov/pubmed/33564775
http://dx.doi.org/10.1101/2021.02.01.21250493
Descripción
Sumario:The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has now caused over 2 million deaths worldwide and continues to expand. Currently, much is unknown about functionally neutralizing human antibody responses and durability to SARS-CoV-2. Using convalescent sera collected from 101 COVID-19 recovered individuals 21–212 days after symptom onset with forty-eight additional longitudinal samples, we measured functionality and durability of serum antibodies. We also evaluated associations between individual demographic and clinical parameters with functional neutralizing antibody responses to COVID-19. We found robust antibody durability out to six months, as well as significant positive associations with the magnitude of the neutralizing antibody response and male sex. We also show that SARS-CoV-2 convalescent neutralizing antibodies are higher in individuals with cardio-metabolic comorbidities.

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