Tricyclo[2.1.0.0(2,5)]pent-3-ylidene: Stereoelectronic Control of Bridge-Flapping within a Nonclassical Nucleophilic Carbene

[Image: see text] Tricyclo[2.1.0.0(2,5)]pent-3-ylidene is a carbene foreseen to rearrange to pyramidane (c-C(4)H(4))C, a highly strained molecule featuring an inverted C atom. Modeling of the carbene, using the (U)MPWB1K/cc-pVTZ//(U)MPWB1K/6-311G(d) theoretical model, indicated a large singlet–triplet energy gap (ΔE(S–T) = −45 kcal/mol), a high gas-phase proton affinity (PA = 258 kcal/mol), and a preference for electron-poor alkenes. These properties are consistent with those of nucleophilic carbenes. Structural differences between the C(s)-symmetric singlet (ω(flap) = ±44 deg) and C(2v)-symmetric triplet (ω(flap) = 0 deg) stem from nonclassical electron delocalization in the former and the lack thereof in the latter. Degenerate bridge-flapping of the singlet’s main bridge, which comprises the reactive divalent C3 atom, is computed to be slow due to a high activation barrier of the C(2v)-symmetric transition state (TS) (E(a) = 17 kcal/mol). The position of the conformeric equilibrium is subject to stereoelectronic control. 1-Substituted derivatives of the carbene (R ≠ H) are sensitive to σ inductive effects. A proximal conformation is preferred when R is electron-donating and a distal one is favored when R is electron-withdrawing. Finally, carbene rearrangements via 1,2-C atom shift or enyne fragmentation were computed. The C(2v)-symmetric bridge-flapping TS has the proper geometry to initiate enyne fragmentation.