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An integrative study of five biological clocks in somatic and mental health

Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined...

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Autores principales: Jansen, Rick, Han, Laura KM, Verhoeven, Josine E, Aberg, Karolina A, van den Oord, Edwin CGJ, Milaneschi, Yuri, Penninx, Brenda WJH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872513/
https://www.ncbi.nlm.nih.gov/pubmed/33558008
http://dx.doi.org/10.7554/eLife.59479
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author Jansen, Rick
Han, Laura KM
Verhoeven, Josine E
Aberg, Karolina A
van den Oord, Edwin CGJ
Milaneschi, Yuri
Penninx, Brenda WJH
author_facet Jansen, Rick
Han, Laura KM
Verhoeven, Josine E
Aberg, Karolina A
van den Oord, Edwin CGJ
Milaneschi, Yuri
Penninx, Brenda WJH
author_sort Jansen, Rick
collection PubMed
description Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic clocks) were interrelated and associated to somatic and mental health determinants. Correlations between biological aging indicators were small (all r < 0.2), indicating little overlap. The most consistent associations of advanced biological aging were found for male sex, higher body mass index (BMI), metabolic syndrome, smoking, and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological aging indicators suggest that one’s biological age is best reflected by combining aging measures from multiple cellular levels.
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spelling pubmed-78725132021-02-10 An integrative study of five biological clocks in somatic and mental health Jansen, Rick Han, Laura KM Verhoeven, Josine E Aberg, Karolina A van den Oord, Edwin CGJ Milaneschi, Yuri Penninx, Brenda WJH eLife Cell Biology Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic clocks) were interrelated and associated to somatic and mental health determinants. Correlations between biological aging indicators were small (all r < 0.2), indicating little overlap. The most consistent associations of advanced biological aging were found for male sex, higher body mass index (BMI), metabolic syndrome, smoking, and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological aging indicators suggest that one’s biological age is best reflected by combining aging measures from multiple cellular levels. eLife Sciences Publications, Ltd 2021-02-09 /pmc/articles/PMC7872513/ /pubmed/33558008 http://dx.doi.org/10.7554/eLife.59479 Text en © 2021, Jansen et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Jansen, Rick
Han, Laura KM
Verhoeven, Josine E
Aberg, Karolina A
van den Oord, Edwin CGJ
Milaneschi, Yuri
Penninx, Brenda WJH
An integrative study of five biological clocks in somatic and mental health
title An integrative study of five biological clocks in somatic and mental health
title_full An integrative study of five biological clocks in somatic and mental health
title_fullStr An integrative study of five biological clocks in somatic and mental health
title_full_unstemmed An integrative study of five biological clocks in somatic and mental health
title_short An integrative study of five biological clocks in somatic and mental health
title_sort integrative study of five biological clocks in somatic and mental health
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872513/
https://www.ncbi.nlm.nih.gov/pubmed/33558008
http://dx.doi.org/10.7554/eLife.59479
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