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There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia
INTRODUCTION: There is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both. METHODS: This re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872822/ https://www.ncbi.nlm.nih.gov/pubmed/33564974 http://dx.doi.org/10.1007/s11845-021-02545-y |
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author | Williamson, Joseph Black, Louisa Black, Anna Koduri, Gouri Kelly, Clive |
author_facet | Williamson, Joseph Black, Louisa Black, Anna Koduri, Gouri Kelly, Clive |
author_sort | Williamson, Joseph |
collection | PubMed |
description | INTRODUCTION: There is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both. METHODS: This review explores this overlap of clinical features, risk factors and causation, offering insights into the immune mechanisms that contribute to both sets of disorders. RESULTS: The therapeutic role of immunosuppression and biologic agents in the treatment of covid-19 is explained in the light of this. DISCUSSION: We propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other. |
format | Online Article Text |
id | pubmed-7872822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-78728222021-02-10 There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia Williamson, Joseph Black, Louisa Black, Anna Koduri, Gouri Kelly, Clive Ir J Med Sci Review Article INTRODUCTION: There is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both. METHODS: This review explores this overlap of clinical features, risk factors and causation, offering insights into the immune mechanisms that contribute to both sets of disorders. RESULTS: The therapeutic role of immunosuppression and biologic agents in the treatment of covid-19 is explained in the light of this. DISCUSSION: We propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other. Springer International Publishing 2021-02-10 2022 /pmc/articles/PMC7872822/ /pubmed/33564974 http://dx.doi.org/10.1007/s11845-021-02545-y Text en © Royal Academy of Medicine in Ireland 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Williamson, Joseph Black, Louisa Black, Anna Koduri, Gouri Kelly, Clive There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia |
title | There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia |
title_full | There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia |
title_fullStr | There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia |
title_full_unstemmed | There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia |
title_short | There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia |
title_sort | there are similarities between rheumatic disease with lung involvement and covid-19 pneumonia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872822/ https://www.ncbi.nlm.nih.gov/pubmed/33564974 http://dx.doi.org/10.1007/s11845-021-02545-y |
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