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The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients

BACKGROUND/OBJECTIVES: A dysregulated inflammatory profile plays an important role in coronavirus disease-2019 (COVID-19) pathogenesis. Moreover, the depletion of lymphocytes is typically associated with an unfavourable disease course. We studied the role and impact of p53 and deacetylase Sirtuin 1...

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Detalles Bibliográficos
Autores principales:	Bordoni, Veronica, Tartaglia, Eleonora, Sacchi, Alessandra, Fimia, Gian Maria, Cimini, Eleonora, Casetti, Rita, Notari, Stefania, Grassi, Germana, Marchioni, Luisa, Bibas, Michele, Capobianchi, Maria R., Locatelli, Franco, Maeurer, Markus, Zumla, Alimuddin, Antinori, Andrea, Nicastri, Emanuele, Ippolito, Giuseppe, Agrati, Chiara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872850/ https://www.ncbi.nlm.nih.gov/pubmed/33578018 http://dx.doi.org/10.1016/j.ijid.2021.02.019

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