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siRNA Knockdown of REDD1 Facilitates Aspirin-Mediated Dephosphorylation of mTORC1 Target 4E-BP1 in MDA-MB-468 Human Breast Cancer Cell Line

BACKGROUND: Mutations within genes encoding components of the PI3K/AKT/mTOR (phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin) signaling axis frequently activate the pathway in breast cancer, making it an attractive therapeutic target. Inhibition of mTORC1 (mechanistic targ...

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Detalles Bibliográficos
Autores principales:	Savukaitytė, Aistė, Gudoitytė, Greta, Bartnykaitė, Agnė, Ugenskienė, Rasa, Juozaitytė, Elona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872862/ https://www.ncbi.nlm.nih.gov/pubmed/33574709 http://dx.doi.org/10.2147/CMAR.S264414

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