Herpes simplex virus-2 associated with a large fungating penile mass

A 48-year-old male with HIV/AIDS presented with an enlarging nodular lesion on the base of his penis. Histology revealed changes consistent with chronic viral infection and culture grew herpes simplex virus 2 (HSV-2). The lesion was refractory to valacyclovir and intralesional (IL) cidofovir therapy...

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Detalles Bibliográficos
Autores principales: Bowman, Max S., Lang, Ursula E., Leslie, Kieron S., Amend, Gregory, Breyer, Benjamin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Inflammation and Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872973/
https://www.ncbi.nlm.nih.gov/pubmed/33604244
http://dx.doi.org/10.1016/j.eucr.2021.101594
Descripción
Sumario:A 48-year-old male with HIV/AIDS presented with an enlarging nodular lesion on the base of his penis. Histology revealed changes consistent with chronic viral infection and culture grew herpes simplex virus 2 (HSV-2). The lesion was refractory to valacyclovir and intralesional (IL) cidofovir therapy. Urology excised the mass and the defect was repaired primarily with good cosmetic result. Post-operative pathology confirmed HSV-2 despite the unusual appearance of the lesion consisting of nodular mass without gross ulceration.

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