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High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings

Antibiotic resistance is a global health crisis that requires urgent action to stop its spread. To counteract the spread of antibiotic resistance, we must improve our understanding of the origin and spread of resistant bacteria in both community and healthcare settings. Unfortunately, little attenti...

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Autores principales: Nji, Emmanuel, Kazibwe, Joseph, Hambridge, Thomas, Joko, Carolyn Alia, Larbi, Amma Aboagyewa, Damptey, Lois Afua Okyerewaa, Nkansa-Gyamfi, Nana Adoma, Stålsby Lundborg, Cecilia, Lien, La Thi Quynh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873077/
https://www.ncbi.nlm.nih.gov/pubmed/33564047
http://dx.doi.org/10.1038/s41598-021-82693-4
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author Nji, Emmanuel
Kazibwe, Joseph
Hambridge, Thomas
Joko, Carolyn Alia
Larbi, Amma Aboagyewa
Damptey, Lois Afua Okyerewaa
Nkansa-Gyamfi, Nana Adoma
Stålsby Lundborg, Cecilia
Lien, La Thi Quynh
author_facet Nji, Emmanuel
Kazibwe, Joseph
Hambridge, Thomas
Joko, Carolyn Alia
Larbi, Amma Aboagyewa
Damptey, Lois Afua Okyerewaa
Nkansa-Gyamfi, Nana Adoma
Stålsby Lundborg, Cecilia
Lien, La Thi Quynh
author_sort Nji, Emmanuel
collection PubMed
description Antibiotic resistance is a global health crisis that requires urgent action to stop its spread. To counteract the spread of antibiotic resistance, we must improve our understanding of the origin and spread of resistant bacteria in both community and healthcare settings. Unfortunately, little attention is being given to contain the spread of antibiotic resistance in community settings (i.e., locations outside of a hospital inpatient, acute care setting, or a hospital clinic setting), despite some studies have consistently reported a high prevalence of antibiotic resistance in the community settings. This study aimed to investigate the prevalence of antibiotic resistance in commensal Escherichia coli isolates from healthy humans in community settings in LMICs. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we synthesized studies conducted from 1989 to May 2020. A total of 9363 articles were obtained from the search and prevalence data were extracted from 33 articles and pooled together. This gave a pooled prevalence of antibiotic resistance (top ten antibiotics commonly prescribed in LMICs) in commensal E. coli isolates from human sources in community settings in LMICs of: ampicillin (72% of 13,531 isolates, 95% CI: 65–79), cefotaxime (27% of 6700 isolates, 95% CI: 12–44), chloramphenicol (45% of 7012 isolates, 95% CI: 35–53), ciprofloxacin (17% of 10,618 isolates, 95% CI: 11–25), co-trimoxazole (63% of 10,561 isolates, 95% CI: 52–73), nalidixic acid (30% of 9819 isolates, 95% CI: 21–40), oxytetracycline (78% of 1451 isolates, 95% CI: 65–88), streptomycin (58% of 3831 isolates, 95% CI: 44–72), tetracycline (67% of 11,847 isolates, 95% CI: 59–74), and trimethoprim (67% of 3265 isolates, 95% CI: 59–75). Here, we provided an appraisal of the evidence of the high prevalence of antibiotic resistance by commensal E. coli in community settings in LMICs. Our findings will have important ramifications for public health policy design to contain the spread of antibiotic resistance in community settings. Indeed, commensal E. coli is the main reservoir for spreading antibiotic resistance to other pathogenic enteric bacteria via mobile genetic elements.
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spelling pubmed-78730772021-02-10 High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings Nji, Emmanuel Kazibwe, Joseph Hambridge, Thomas Joko, Carolyn Alia Larbi, Amma Aboagyewa Damptey, Lois Afua Okyerewaa Nkansa-Gyamfi, Nana Adoma Stålsby Lundborg, Cecilia Lien, La Thi Quynh Sci Rep Article Antibiotic resistance is a global health crisis that requires urgent action to stop its spread. To counteract the spread of antibiotic resistance, we must improve our understanding of the origin and spread of resistant bacteria in both community and healthcare settings. Unfortunately, little attention is being given to contain the spread of antibiotic resistance in community settings (i.e., locations outside of a hospital inpatient, acute care setting, or a hospital clinic setting), despite some studies have consistently reported a high prevalence of antibiotic resistance in the community settings. This study aimed to investigate the prevalence of antibiotic resistance in commensal Escherichia coli isolates from healthy humans in community settings in LMICs. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we synthesized studies conducted from 1989 to May 2020. A total of 9363 articles were obtained from the search and prevalence data were extracted from 33 articles and pooled together. This gave a pooled prevalence of antibiotic resistance (top ten antibiotics commonly prescribed in LMICs) in commensal E. coli isolates from human sources in community settings in LMICs of: ampicillin (72% of 13,531 isolates, 95% CI: 65–79), cefotaxime (27% of 6700 isolates, 95% CI: 12–44), chloramphenicol (45% of 7012 isolates, 95% CI: 35–53), ciprofloxacin (17% of 10,618 isolates, 95% CI: 11–25), co-trimoxazole (63% of 10,561 isolates, 95% CI: 52–73), nalidixic acid (30% of 9819 isolates, 95% CI: 21–40), oxytetracycline (78% of 1451 isolates, 95% CI: 65–88), streptomycin (58% of 3831 isolates, 95% CI: 44–72), tetracycline (67% of 11,847 isolates, 95% CI: 59–74), and trimethoprim (67% of 3265 isolates, 95% CI: 59–75). Here, we provided an appraisal of the evidence of the high prevalence of antibiotic resistance by commensal E. coli in community settings in LMICs. Our findings will have important ramifications for public health policy design to contain the spread of antibiotic resistance in community settings. Indeed, commensal E. coli is the main reservoir for spreading antibiotic resistance to other pathogenic enteric bacteria via mobile genetic elements. Nature Publishing Group UK 2021-02-09 /pmc/articles/PMC7873077/ /pubmed/33564047 http://dx.doi.org/10.1038/s41598-021-82693-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Nji, Emmanuel
Kazibwe, Joseph
Hambridge, Thomas
Joko, Carolyn Alia
Larbi, Amma Aboagyewa
Damptey, Lois Afua Okyerewaa
Nkansa-Gyamfi, Nana Adoma
Stålsby Lundborg, Cecilia
Lien, La Thi Quynh
High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings
title High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings
title_full High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings
title_fullStr High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings
title_full_unstemmed High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings
title_short High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings
title_sort high prevalence of antibiotic resistance in commensal escherichia coli from healthy human sources in community settings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873077/
https://www.ncbi.nlm.nih.gov/pubmed/33564047
http://dx.doi.org/10.1038/s41598-021-82693-4
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