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High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings
Antibiotic resistance is a global health crisis that requires urgent action to stop its spread. To counteract the spread of antibiotic resistance, we must improve our understanding of the origin and spread of resistant bacteria in both community and healthcare settings. Unfortunately, little attenti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873077/ https://www.ncbi.nlm.nih.gov/pubmed/33564047 http://dx.doi.org/10.1038/s41598-021-82693-4 |
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author | Nji, Emmanuel Kazibwe, Joseph Hambridge, Thomas Joko, Carolyn Alia Larbi, Amma Aboagyewa Damptey, Lois Afua Okyerewaa Nkansa-Gyamfi, Nana Adoma Stålsby Lundborg, Cecilia Lien, La Thi Quynh |
author_facet | Nji, Emmanuel Kazibwe, Joseph Hambridge, Thomas Joko, Carolyn Alia Larbi, Amma Aboagyewa Damptey, Lois Afua Okyerewaa Nkansa-Gyamfi, Nana Adoma Stålsby Lundborg, Cecilia Lien, La Thi Quynh |
author_sort | Nji, Emmanuel |
collection | PubMed |
description | Antibiotic resistance is a global health crisis that requires urgent action to stop its spread. To counteract the spread of antibiotic resistance, we must improve our understanding of the origin and spread of resistant bacteria in both community and healthcare settings. Unfortunately, little attention is being given to contain the spread of antibiotic resistance in community settings (i.e., locations outside of a hospital inpatient, acute care setting, or a hospital clinic setting), despite some studies have consistently reported a high prevalence of antibiotic resistance in the community settings. This study aimed to investigate the prevalence of antibiotic resistance in commensal Escherichia coli isolates from healthy humans in community settings in LMICs. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we synthesized studies conducted from 1989 to May 2020. A total of 9363 articles were obtained from the search and prevalence data were extracted from 33 articles and pooled together. This gave a pooled prevalence of antibiotic resistance (top ten antibiotics commonly prescribed in LMICs) in commensal E. coli isolates from human sources in community settings in LMICs of: ampicillin (72% of 13,531 isolates, 95% CI: 65–79), cefotaxime (27% of 6700 isolates, 95% CI: 12–44), chloramphenicol (45% of 7012 isolates, 95% CI: 35–53), ciprofloxacin (17% of 10,618 isolates, 95% CI: 11–25), co-trimoxazole (63% of 10,561 isolates, 95% CI: 52–73), nalidixic acid (30% of 9819 isolates, 95% CI: 21–40), oxytetracycline (78% of 1451 isolates, 95% CI: 65–88), streptomycin (58% of 3831 isolates, 95% CI: 44–72), tetracycline (67% of 11,847 isolates, 95% CI: 59–74), and trimethoprim (67% of 3265 isolates, 95% CI: 59–75). Here, we provided an appraisal of the evidence of the high prevalence of antibiotic resistance by commensal E. coli in community settings in LMICs. Our findings will have important ramifications for public health policy design to contain the spread of antibiotic resistance in community settings. Indeed, commensal E. coli is the main reservoir for spreading antibiotic resistance to other pathogenic enteric bacteria via mobile genetic elements. |
format | Online Article Text |
id | pubmed-7873077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78730772021-02-10 High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings Nji, Emmanuel Kazibwe, Joseph Hambridge, Thomas Joko, Carolyn Alia Larbi, Amma Aboagyewa Damptey, Lois Afua Okyerewaa Nkansa-Gyamfi, Nana Adoma Stålsby Lundborg, Cecilia Lien, La Thi Quynh Sci Rep Article Antibiotic resistance is a global health crisis that requires urgent action to stop its spread. To counteract the spread of antibiotic resistance, we must improve our understanding of the origin and spread of resistant bacteria in both community and healthcare settings. Unfortunately, little attention is being given to contain the spread of antibiotic resistance in community settings (i.e., locations outside of a hospital inpatient, acute care setting, or a hospital clinic setting), despite some studies have consistently reported a high prevalence of antibiotic resistance in the community settings. This study aimed to investigate the prevalence of antibiotic resistance in commensal Escherichia coli isolates from healthy humans in community settings in LMICs. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we synthesized studies conducted from 1989 to May 2020. A total of 9363 articles were obtained from the search and prevalence data were extracted from 33 articles and pooled together. This gave a pooled prevalence of antibiotic resistance (top ten antibiotics commonly prescribed in LMICs) in commensal E. coli isolates from human sources in community settings in LMICs of: ampicillin (72% of 13,531 isolates, 95% CI: 65–79), cefotaxime (27% of 6700 isolates, 95% CI: 12–44), chloramphenicol (45% of 7012 isolates, 95% CI: 35–53), ciprofloxacin (17% of 10,618 isolates, 95% CI: 11–25), co-trimoxazole (63% of 10,561 isolates, 95% CI: 52–73), nalidixic acid (30% of 9819 isolates, 95% CI: 21–40), oxytetracycline (78% of 1451 isolates, 95% CI: 65–88), streptomycin (58% of 3831 isolates, 95% CI: 44–72), tetracycline (67% of 11,847 isolates, 95% CI: 59–74), and trimethoprim (67% of 3265 isolates, 95% CI: 59–75). Here, we provided an appraisal of the evidence of the high prevalence of antibiotic resistance by commensal E. coli in community settings in LMICs. Our findings will have important ramifications for public health policy design to contain the spread of antibiotic resistance in community settings. Indeed, commensal E. coli is the main reservoir for spreading antibiotic resistance to other pathogenic enteric bacteria via mobile genetic elements. Nature Publishing Group UK 2021-02-09 /pmc/articles/PMC7873077/ /pubmed/33564047 http://dx.doi.org/10.1038/s41598-021-82693-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nji, Emmanuel Kazibwe, Joseph Hambridge, Thomas Joko, Carolyn Alia Larbi, Amma Aboagyewa Damptey, Lois Afua Okyerewaa Nkansa-Gyamfi, Nana Adoma Stålsby Lundborg, Cecilia Lien, La Thi Quynh High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
title | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
title_full | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
title_fullStr | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
title_full_unstemmed | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
title_short | High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings |
title_sort | high prevalence of antibiotic resistance in commensal escherichia coli from healthy human sources in community settings |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873077/ https://www.ncbi.nlm.nih.gov/pubmed/33564047 http://dx.doi.org/10.1038/s41598-021-82693-4 |
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