From immune to olfactory expression: neofunctionalization of formyl peptide receptors

Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an...

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Detalles Bibliográficos
Autores principales: Boillat, Madlaina, Carleton, Alan, Rodriguez, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
At-a-glance Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873101/
https://www.ncbi.nlm.nih.gov/pubmed/33452930
http://dx.doi.org/10.1007/s00441-020-03393-5
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author Boillat, Madlaina
Carleton, Alan
Rodriguez, Ivan
author_facet Boillat, Madlaina
Carleton, Alan
Rodriguez, Ivan
author_sort Boillat, Madlaina
collection PubMed
description Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an immune pathogen sensor to transition into an olfactory chemoreceptor, which thus moved from sensing the internal world to probing the outside world. We here discuss the evolution of the FPR gene family, the events that led to their neofunctionalization in the vomeronasal organ and the functions of immune and vomeronasal FPRs.
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spelling pubmed-78731012021-02-22 From immune to olfactory expression: neofunctionalization of formyl peptide receptors Boillat, Madlaina Carleton, Alan Rodriguez, Ivan Cell Tissue Res At-a-glance Article Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an immune pathogen sensor to transition into an olfactory chemoreceptor, which thus moved from sensing the internal world to probing the outside world. We here discuss the evolution of the FPR gene family, the events that led to their neofunctionalization in the vomeronasal organ and the functions of immune and vomeronasal FPRs. Springer Berlin Heidelberg 2021-01-16 2021 /pmc/articles/PMC7873101/ /pubmed/33452930 http://dx.doi.org/10.1007/s00441-020-03393-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle At-a-glance Article
Boillat, Madlaina
Carleton, Alan
Rodriguez, Ivan
From immune to olfactory expression: neofunctionalization of formyl peptide receptors
title From immune to olfactory expression: neofunctionalization of formyl peptide receptors
title_full From immune to olfactory expression: neofunctionalization of formyl peptide receptors
title_fullStr From immune to olfactory expression: neofunctionalization of formyl peptide receptors
title_full_unstemmed From immune to olfactory expression: neofunctionalization of formyl peptide receptors
title_short From immune to olfactory expression: neofunctionalization of formyl peptide receptors
title_sort from immune to olfactory expression: neofunctionalization of formyl peptide receptors
topic At-a-glance Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873101/
https://www.ncbi.nlm.nih.gov/pubmed/33452930
http://dx.doi.org/10.1007/s00441-020-03393-5
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