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The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a...

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Detalles Bibliográficos
Autores principales:	Davydova, Erna, Shimazu, Tadahiro, Schuhmacher, Maren Kirstin, Jakobsson, Magnus E., Willemen, Hanneke L. D. M., Liu, Tongri, Moen, Anders, Ho, Angela Y. Y., Małecki, Jędrzej, Schroer, Lisa, Pinto, Rita, Suzuki, Takehiro, Grønsberg, Ida A., Sohtome, Yoshihiro, Akakabe, Mai, Weirich, Sara, Kikuchi, Masaki, Olsen, Jesper V., Dohmae, Naoshi, Umehara, Takashi, Sodeoka, Mikiko, Siino, Valentina, McDonough, Michael A., Eijkelkamp, Niels, Schofield, Christopher J., Jeltsch, Albert, Shinkai, Yoichi, Falnes, Pål Ø.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873184/ https://www.ncbi.nlm.nih.gov/pubmed/33563959 http://dx.doi.org/10.1038/s41467-020-20670-7

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