Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1

Acid-sensing ion channels (ASICs) are proton-gated cation channels critical for neuronal functions. Studies of ASIC1, a major ASIC isoform and proton sensor, have identified acidic pocket, an extracellular region enriched in acidic residues, as a key participant in channel gating. While binding to t...

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Detalles Bibliográficos
Autores principales: Liu, Yi, Ma, Jichun, DesJarlais, Renee L., Hagan, Rebecca, Rech, Jason, Lin, David, Liu, Changlu, Miller, Robyn, Schoellerman, Jeffrey, Luo, Jinquan, Letavic, Michael, Grasberger, Bruce, Maher, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873226/
https://www.ncbi.nlm.nih.gov/pubmed/33564124
http://dx.doi.org/10.1038/s42003-021-01678-1

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