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A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats
Individuals with spinal cord injury or neurological disorders have problems in voiding function due to the dyssynergic contraction of the urethral sphincter. Here, we introduce a closed-loop control of intraspinal microstimulation (ISMS) for efficient bladder voiding. The strategy is based on asynch...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873267/ https://www.ncbi.nlm.nih.gov/pubmed/33564019 http://dx.doi.org/10.1038/s41598-021-82933-7 |
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author | Yousefpour, Abolhasan Erfanian, Abbas |
author_facet | Yousefpour, Abolhasan Erfanian, Abbas |
author_sort | Yousefpour, Abolhasan |
collection | PubMed |
description | Individuals with spinal cord injury or neurological disorders have problems in voiding function due to the dyssynergic contraction of the urethral sphincter. Here, we introduce a closed-loop control of intraspinal microstimulation (ISMS) for efficient bladder voiding. The strategy is based on asynchronous two-electrode ISMS with combined pulse-amplitude and pulse-frequency modulation without requiring rhizotomy, neurotomy, or high-frequency blocking. Intermittent stimulation is alternately applied to the two electrodes that are implanted in the S2 lateral ventral horn and S1 dorsal gray commissure, to excite the bladder motoneurons and to inhibit the urethral sphincter motoneurons. Asynchronous stimulation would lead to reduce the net electric field and to maximize the selective stimulation. The proposed closed-loop system attains a highly voiding efficiency of 77.2–100%, with an average of 91.28 ± 8.4%. This work represents a promising approach to the development of a natural and robust motor neuroprosthesis device for restoring bladder functions. |
format | Online Article Text |
id | pubmed-7873267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78732672021-02-11 A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats Yousefpour, Abolhasan Erfanian, Abbas Sci Rep Article Individuals with spinal cord injury or neurological disorders have problems in voiding function due to the dyssynergic contraction of the urethral sphincter. Here, we introduce a closed-loop control of intraspinal microstimulation (ISMS) for efficient bladder voiding. The strategy is based on asynchronous two-electrode ISMS with combined pulse-amplitude and pulse-frequency modulation without requiring rhizotomy, neurotomy, or high-frequency blocking. Intermittent stimulation is alternately applied to the two electrodes that are implanted in the S2 lateral ventral horn and S1 dorsal gray commissure, to excite the bladder motoneurons and to inhibit the urethral sphincter motoneurons. Asynchronous stimulation would lead to reduce the net electric field and to maximize the selective stimulation. The proposed closed-loop system attains a highly voiding efficiency of 77.2–100%, with an average of 91.28 ± 8.4%. This work represents a promising approach to the development of a natural and robust motor neuroprosthesis device for restoring bladder functions. Nature Publishing Group UK 2021-02-09 /pmc/articles/PMC7873267/ /pubmed/33564019 http://dx.doi.org/10.1038/s41598-021-82933-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yousefpour, Abolhasan Erfanian, Abbas A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats |
title | A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats |
title_full | A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats |
title_fullStr | A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats |
title_full_unstemmed | A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats |
title_short | A general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats |
title_sort | general framework for automatic closed-loop control of bladder voiding induced by intraspinal microstimulation in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873267/ https://www.ncbi.nlm.nih.gov/pubmed/33564019 http://dx.doi.org/10.1038/s41598-021-82933-7 |
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