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Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic domain belonging to the EndoU family that is highly conserved in coronaviruses. As endoribonuclease activity seems to be responsible for the interference with the innate immune response, Nsp15 emerges as an attractive...

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Detalles Bibliográficos
Autores principales:	Kim, Youngchang, Wower, Jacek, Maltseva, Natalia, Chang, Changsoo, Jedrzejczak, Robert, Wilamowski, Mateusz, Kang, Soowon, Nicolaescu, Vlad, Randall, Glenn, Michalska, Karolina, Joachimiak, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873276/ https://www.ncbi.nlm.nih.gov/pubmed/33564093 http://dx.doi.org/10.1038/s42003-021-01735-9

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