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Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex

Prefrontal cortex is critical for cognition. Although much is known about the representation of cognitive variables in the prefrontal cortex, much less is known about the spatio-temporal neural dynamics that underlie cognitive operations. In the present study, we examined information timing and flow...

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Autores principales: Tang, Hua, Bartolo, Ramon, Averbeck, Bruno B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873307/
https://www.ncbi.nlm.nih.gov/pubmed/33563989
http://dx.doi.org/10.1038/s41467-021-20943-9
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author Tang, Hua
Bartolo, Ramon
Averbeck, Bruno B.
author_facet Tang, Hua
Bartolo, Ramon
Averbeck, Bruno B.
author_sort Tang, Hua
collection PubMed
description Prefrontal cortex is critical for cognition. Although much is known about the representation of cognitive variables in the prefrontal cortex, much less is known about the spatio-temporal neural dynamics that underlie cognitive operations. In the present study, we examined information timing and flow across the lateral prefrontal cortex (LPFC), while monkeys carried out a two-armed bandit reinforcement learning task in which they had to learn to select rewarding actions or rewarding objects. When we analyzed signals independently within subregions of the LPFC, we found a task-specific, caudo-rostral gradient in the strength and timing of signals related to chosen objects and chosen actions. In addition, when we characterized information flow among subregions, we found that information flow from action to object representations was stronger from the dorsal to ventral LPFC, and information flow from object to action representations was stronger from the ventral to dorsal LPFC. The object to action effects were more pronounced in object blocks, and also reflected learning specifically in these blocks. These results suggest anatomical segregation followed by the rapid integration of information within the LPFC.
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spelling pubmed-78733072021-02-24 Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex Tang, Hua Bartolo, Ramon Averbeck, Bruno B. Nat Commun Article Prefrontal cortex is critical for cognition. Although much is known about the representation of cognitive variables in the prefrontal cortex, much less is known about the spatio-temporal neural dynamics that underlie cognitive operations. In the present study, we examined information timing and flow across the lateral prefrontal cortex (LPFC), while monkeys carried out a two-armed bandit reinforcement learning task in which they had to learn to select rewarding actions or rewarding objects. When we analyzed signals independently within subregions of the LPFC, we found a task-specific, caudo-rostral gradient in the strength and timing of signals related to chosen objects and chosen actions. In addition, when we characterized information flow among subregions, we found that information flow from action to object representations was stronger from the dorsal to ventral LPFC, and information flow from object to action representations was stronger from the ventral to dorsal LPFC. The object to action effects were more pronounced in object blocks, and also reflected learning specifically in these blocks. These results suggest anatomical segregation followed by the rapid integration of information within the LPFC. Nature Publishing Group UK 2021-02-09 /pmc/articles/PMC7873307/ /pubmed/33563989 http://dx.doi.org/10.1038/s41467-021-20943-9 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tang, Hua
Bartolo, Ramon
Averbeck, Bruno B.
Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex
title Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex
title_full Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex
title_fullStr Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex
title_full_unstemmed Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex
title_short Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex
title_sort reward-related choices determine information timing and flow across macaque lateral prefrontal cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873307/
https://www.ncbi.nlm.nih.gov/pubmed/33563989
http://dx.doi.org/10.1038/s41467-021-20943-9
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