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Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study

Neuronal excitation and inhibition occur in the brain at the same time, and brain activation reflects changes in the sum of excitation and inhibition. This principle has been well-established in lower-level sensory systems, including vision and touch, based on animal studies. However, it is unclear...

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Autores principales: Liu, Yang, Dong, Bo, Yang, Jiajia, Ejima, Yoshimichi, Wu, Jinglong, Wu, Qiong, Zhang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873359/
https://www.ncbi.nlm.nih.gov/pubmed/33584236
http://dx.doi.org/10.3389/fninf.2020.571369
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author Liu, Yang
Dong, Bo
Yang, Jiajia
Ejima, Yoshimichi
Wu, Jinglong
Wu, Qiong
Zhang, Ming
author_facet Liu, Yang
Dong, Bo
Yang, Jiajia
Ejima, Yoshimichi
Wu, Jinglong
Wu, Qiong
Zhang, Ming
author_sort Liu, Yang
collection PubMed
description Neuronal excitation and inhibition occur in the brain at the same time, and brain activation reflects changes in the sum of excitation and inhibition. This principle has been well-established in lower-level sensory systems, including vision and touch, based on animal studies. However, it is unclear how the somatosensory system processes the balance between excitation and inhibition. In the present ERP study, we modified the traditional spatial attention paradigm by adding double stimuli presentations at short intervals (i.e., 10, 30, and 100 ms). Seventeen subjects participated in the experiment. Five types of stimulation were used in the experiment: a single stimulus (one raised pin for 40 ms), standard stimulus (eight pins for 40 ms), and double stimuli presented at intervals of 10, 30, and 100 ms. The subjects were asked to attend to a particular finger and detect whether the standard stimulus was presented to that finger. The results showed a clear attention-related ERP component in the single stimulus condition, but the suppression components associated with the three interval conditions seemed to be dominant in somatosensory areas. In particular, we found the strongest suppression effect in the ISI-30 condition (interval of 30 ms) and that the suppression and enhancement effects seemed to be counterbalanced in both the ISI-10 and ISI-100 conditions (intervals of 10 and 100 ms, respectively). This type of processing may allow humans to easily discriminate between multiple stimuli on the same body part.
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spelling pubmed-78733592021-02-11 Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study Liu, Yang Dong, Bo Yang, Jiajia Ejima, Yoshimichi Wu, Jinglong Wu, Qiong Zhang, Ming Front Neuroinform Neuroscience Neuronal excitation and inhibition occur in the brain at the same time, and brain activation reflects changes in the sum of excitation and inhibition. This principle has been well-established in lower-level sensory systems, including vision and touch, based on animal studies. However, it is unclear how the somatosensory system processes the balance between excitation and inhibition. In the present ERP study, we modified the traditional spatial attention paradigm by adding double stimuli presentations at short intervals (i.e., 10, 30, and 100 ms). Seventeen subjects participated in the experiment. Five types of stimulation were used in the experiment: a single stimulus (one raised pin for 40 ms), standard stimulus (eight pins for 40 ms), and double stimuli presented at intervals of 10, 30, and 100 ms. The subjects were asked to attend to a particular finger and detect whether the standard stimulus was presented to that finger. The results showed a clear attention-related ERP component in the single stimulus condition, but the suppression components associated with the three interval conditions seemed to be dominant in somatosensory areas. In particular, we found the strongest suppression effect in the ISI-30 condition (interval of 30 ms) and that the suppression and enhancement effects seemed to be counterbalanced in both the ISI-10 and ISI-100 conditions (intervals of 10 and 100 ms, respectively). This type of processing may allow humans to easily discriminate between multiple stimuli on the same body part. Frontiers Media S.A. 2021-01-27 /pmc/articles/PMC7873359/ /pubmed/33584236 http://dx.doi.org/10.3389/fninf.2020.571369 Text en Copyright © 2021 Liu, Dong, Yang, Ejima, Wu, Wu and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Yang
Dong, Bo
Yang, Jiajia
Ejima, Yoshimichi
Wu, Jinglong
Wu, Qiong
Zhang, Ming
Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study
title Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study
title_full Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study
title_fullStr Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study
title_full_unstemmed Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study
title_short Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study
title_sort stimulus intervals modulate the balance of brain activity in the human primary somatosensory cortex: an erp study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873359/
https://www.ncbi.nlm.nih.gov/pubmed/33584236
http://dx.doi.org/10.3389/fninf.2020.571369
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