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Endoscopic molecular imaging in inflammatory bowel disease

Molecular imaging is a technique for imaging the processes occurring in a living body at a molecular level in real-time, combining molecular cell biology with advanced imaging technologies using molecular probes and fluorescence. Gastrointestinal endoscopic molecular imaging shows great promise for...

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Detalles Bibliográficos
Autores principales: Ham, Nam Seok, Myung, Seung-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for the Study of Intestinal Diseases 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873406/
https://www.ncbi.nlm.nih.gov/pubmed/32299156
http://dx.doi.org/10.5217/ir.2019.09175
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author Ham, Nam Seok
Myung, Seung-Jae
author_facet Ham, Nam Seok
Myung, Seung-Jae
author_sort Ham, Nam Seok
collection PubMed
description Molecular imaging is a technique for imaging the processes occurring in a living body at a molecular level in real-time, combining molecular cell biology with advanced imaging technologies using molecular probes and fluorescence. Gastrointestinal endoscopic molecular imaging shows great promise for improving the identification of neoplasms, providing characterization for patient stratification and assessing the response to molecular targeted therapy. In inflammatory bowel disease, endoscopic molecular imaging can be used to assess disease severity and predict therapeutic response and prognosis. Endoscopic molecular imaging is also able to visualize dysplasia in the presence of background inflammation. Several preclinical and clinical trials have evaluated endoscopic molecular imaging; however, this area is just beginning to evolve, and many issues have not been solved yet. In the future, it is expected that endoscopic molecular imaging will be of increasing interest among clinicians as a new technology for the identification and evaluation of colorectal neoplasm and colitis-associated cancer.
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spelling pubmed-78734062021-02-18 Endoscopic molecular imaging in inflammatory bowel disease Ham, Nam Seok Myung, Seung-Jae Intest Res Review Molecular imaging is a technique for imaging the processes occurring in a living body at a molecular level in real-time, combining molecular cell biology with advanced imaging technologies using molecular probes and fluorescence. Gastrointestinal endoscopic molecular imaging shows great promise for improving the identification of neoplasms, providing characterization for patient stratification and assessing the response to molecular targeted therapy. In inflammatory bowel disease, endoscopic molecular imaging can be used to assess disease severity and predict therapeutic response and prognosis. Endoscopic molecular imaging is also able to visualize dysplasia in the presence of background inflammation. Several preclinical and clinical trials have evaluated endoscopic molecular imaging; however, this area is just beginning to evolve, and many issues have not been solved yet. In the future, it is expected that endoscopic molecular imaging will be of increasing interest among clinicians as a new technology for the identification and evaluation of colorectal neoplasm and colitis-associated cancer. Korean Association for the Study of Intestinal Diseases 2021-01 2020-04-20 /pmc/articles/PMC7873406/ /pubmed/32299156 http://dx.doi.org/10.5217/ir.2019.09175 Text en © Copyright 2021. Korean Association for the Study of Intestinal Diseases. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Ham, Nam Seok
Myung, Seung-Jae
Endoscopic molecular imaging in inflammatory bowel disease
title Endoscopic molecular imaging in inflammatory bowel disease
title_full Endoscopic molecular imaging in inflammatory bowel disease
title_fullStr Endoscopic molecular imaging in inflammatory bowel disease
title_full_unstemmed Endoscopic molecular imaging in inflammatory bowel disease
title_short Endoscopic molecular imaging in inflammatory bowel disease
title_sort endoscopic molecular imaging in inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873406/
https://www.ncbi.nlm.nih.gov/pubmed/32299156
http://dx.doi.org/10.5217/ir.2019.09175
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