Cargando…

SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation

OBJECTIVE: The intestinal epithelium is a rapidly renewing tissue which plays central roles in nutrient uptake, barrier function and the prevention of intestinal inflammation. Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Južnić, Lea, Peuker, Kenneth, Strigli, Anne, Brosch, Mario, Herrmann, Alexander, Häsler, Robert, Koch, Michael, Matthiesen, Liz, Zeissig, Yvonne, Löscher, Britt-Sabina, Nuber, Alexander, Schotta, Gunnar, Neumeister, Volker, Chavakis, Triantafyllos, Kurth, Thomas, Lesche, Mathias, Dahl, Andreas, von Mässenhausen, Anne, Linkermann, Andreas, Schreiber, Stefan, Aden, Konrad, Rosenstiel, Philip C, Franke, Andre, Hampe, Jochen, Zeissig, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Inflammatory Bowel Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873423/ https://www.ncbi.nlm.nih.gov/pubmed/32503845 http://dx.doi.org/10.1136/gutjnl-2020-321339

Ejemplares similares

Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease
por: Uhde, Melanie, et al.
Publicado: (2016)

Intestinal ultrasound for monitoring therapeutic response in patients with ulcerative colitis: results from the TRUST&UC study
por: Maaser, Christian, et al.
Publicado: (2020)

Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence
por: Khaloian, Sevana, et al.
Publicado: (2020)

Is hypertension an extra‐intestinal manifestation of inflammatory bowel disease?
por: Burisch, Johan
Publicado: (2023)

Creeping fat formation and interaction with intestinal disease in Crohn's disease
por: Yin, Yi, et al.
Publicado: (2022)

Survey of UK clinicians’ approaches to decision making in neonatal intestinal failure
por: Cairns, Pamela, et al.
Publicado: (2022)

IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
por: Ullrich, Karen Anne-Marie, et al.
Publicado: (2023)

EUS-guided stent removal in buried lumen-apposing metal stent syndrome: a case series
por: Biedermann, Julia, et al.
Publicado: (2019)

Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet
por: Wallenius, Ville, et al.
Publicado: (2020)

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse
por: Arrieta, M C, et al.
Publicado: (2008)

Reversal of intestinal failure-associated liver disease (IFALD): emphasis on its multifactorial nature
por: Hvas, Christian, et al.
Publicado: (2016)

Increased Epithelial Gaps in the Small Intestine Are Predictive of Hospitalization and Surgery in Patients With Inflammatory Bowel Disease
por: Turcotte, Jean-Francois, et al.
Publicado: (2012)

Immunological consequences of kidney cell death
por: Sarhan, Maysa, et al.
Publicado: (2018)

Gut virome-colonising Orthohepadnavirus genus is associated with ulcerative colitis pathogenesis and induces intestinal inflammation in vivo
por: Massimino, Luca, et al.
Publicado: (2023)

Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition
por: Binion, D G, et al.
Publicado: (2008)

Clinical management of the most common extra-intestinal manifestations in patients with inflammatory bowel disease focused on the joints, skin and eyes
por: Jansen, Fenna M, et al.
Publicado: (2020)

Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
por: Martínez-Sánchez, Luz del Carmen, et al.
Publicado: (2023)

Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease
por: Häsler, Robert, et al.
Publicado: (2017)

Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI
por: Murray, Kathryn, et al.
Publicado: (2014)

Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn's disease
por: Manon‐Jensen, T., et al.
Publicado: (2021)

Specific neurophysiological mechanisms underlie cognitive inflexibility in inflammatory bowel disease
por: Petruo, Vanessa A, et al.
Publicado: (2017)

Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)
por: Subramanian, Pallavi, et al.
Publicado: (2022)

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease
por: Schwerd, Tobias, et al.
Publicado: (2017)

Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study
por: Murthy, Sanjay K, et al.
Publicado: (2020)

Exit strategies from the COVID-19 lockdown for children and young people receiving home parenteral nutrition (HPN): lessons from the BSPGHAN Intestinal Failure Working Group experience
por: Barclay, Andrew Robert, et al.
Publicado: (2020)

A novel unconventional T cell population enriched in Crohn’s disease
por: Rosati, Elisa, et al.
Publicado: (2022)

Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State
por: Arnone, Djésia, et al.
Publicado: (2021)

Boredom as the originator of a desideratum - reflections on the creative and suppressive consequences of boredom in the school context
por: Zeißig, Anke
Publicado: (2023)

Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion
por: von Mässenhausen, Anne, et al.
Publicado: (2022)

A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group
por: Keller, Josbert J., et al.
Publicado: (2021)

Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice
por: Singh, Rashim Pal, et al.
Publicado: (2018)

Four-Year Maintenance Treatment With Adalimumab in Patients with Moderately to Severely Active Ulcerative Colitis: Data from ULTRA 1, 2, and 3
por: Colombel, Jean-Frederic, et al.
Publicado: (2014)

Subclinical Pulmonary Involvement in Active IBD Responds to Biologic Therapy
por: Ellrichmann, M, et al.
Publicado: (2021)

Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
por: Jeppesen, P B, et al.
Publicado: (2011)

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways
por: Günther, Claudia, et al.
Publicado: (2015)

Panenteric capsule endoscopy identifies proximal small bowel disease guiding upstaging and treatment intensification in Crohn's disease: A European multicentre observational cohort study
por: Tai, Foong Way D., et al.
Publicado: (2021)

Loss of hepatic Mboat7 leads to liver fibrosis
por: Thangapandi, Veera Raghavan, et al.
Publicado: (2021)

Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury
por: Tonnus, Wulf, et al.
Publicado: (2022)

Factors affecting outcomes in Crohn's disease over 15 years
por: Cosnes, Jacques, et al.
Publicado: (2012)

Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet
por: Vervier, Kevin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u2bumhctsqlq1ecbndhl6cobh9