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Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020

This paper describes the epidemiology of coronavirus disease 2019 (COVID-19) in Northern Ireland (NI) between 26 February 2020 and 26 April 2020, and analyses enhanced surveillance and contact tracing data collected between 26 February 2020 and 13 March 2020 to estimate secondary attack rates (SAR)...

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Detalles Bibliográficos
Autores principales: Pett, J., McAleavey, P., McGurnaghan, P., Spiers, R., O'Doherty, M., Patterson, L., Johnston, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873460/
https://www.ncbi.nlm.nih.gov/pubmed/33509318
http://dx.doi.org/10.1017/S0950268821000224
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author Pett, J.
McAleavey, P.
McGurnaghan, P.
Spiers, R.
O'Doherty, M.
Patterson, L.
Johnston, J.
author_facet Pett, J.
McAleavey, P.
McGurnaghan, P.
Spiers, R.
O'Doherty, M.
Patterson, L.
Johnston, J.
author_sort Pett, J.
collection PubMed
description This paper describes the epidemiology of coronavirus disease 2019 (COVID-19) in Northern Ireland (NI) between 26 February 2020 and 26 April 2020, and analyses enhanced surveillance and contact tracing data collected between 26 February 2020 and 13 March 2020 to estimate secondary attack rates (SAR) and relative risk of infection among different categories of contacts of individuals with laboratory confirmed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Our results show that during the study period COVID-19 cumulative incidence and mortality was lower in NI than the rest of the UK. Incidence and mortality were also lower than in the Republic of Ireland (ROI), although these observed differences are difficult to interpret given considerable differences in testing and surveillance between the two nations. SAR among household contacts was 15.9% (95% CI 6.6%–30.1%), over 6 times higher than the SAR among ‘high-risk’ contacts at 2.5% (95% CI 0.9%–5.4%). The results from logistic regression analysis of testing data on contacts of laboratory-confirmed cases show that household contacts had 11.0 times higher odds (aOR: 11.0, 95% CI 1.7–70.03, P-value: 0.011) of testing positive for SARS-CoV-2 compared to other categories of contacts. These results demonstrate the importance of the household as a locus of SARS-CoV-2 transmission, and the urgency of identifying effective interventions to reduce household transmission.
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spelling pubmed-78734602021-02-10 Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020 Pett, J. McAleavey, P. McGurnaghan, P. Spiers, R. O'Doherty, M. Patterson, L. Johnston, J. Epidemiol Infect Original Paper This paper describes the epidemiology of coronavirus disease 2019 (COVID-19) in Northern Ireland (NI) between 26 February 2020 and 26 April 2020, and analyses enhanced surveillance and contact tracing data collected between 26 February 2020 and 13 March 2020 to estimate secondary attack rates (SAR) and relative risk of infection among different categories of contacts of individuals with laboratory confirmed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Our results show that during the study period COVID-19 cumulative incidence and mortality was lower in NI than the rest of the UK. Incidence and mortality were also lower than in the Republic of Ireland (ROI), although these observed differences are difficult to interpret given considerable differences in testing and surveillance between the two nations. SAR among household contacts was 15.9% (95% CI 6.6%–30.1%), over 6 times higher than the SAR among ‘high-risk’ contacts at 2.5% (95% CI 0.9%–5.4%). The results from logistic regression analysis of testing data on contacts of laboratory-confirmed cases show that household contacts had 11.0 times higher odds (aOR: 11.0, 95% CI 1.7–70.03, P-value: 0.011) of testing positive for SARS-CoV-2 compared to other categories of contacts. These results demonstrate the importance of the household as a locus of SARS-CoV-2 transmission, and the urgency of identifying effective interventions to reduce household transmission. Cambridge University Press 2021-01-29 /pmc/articles/PMC7873460/ /pubmed/33509318 http://dx.doi.org/10.1017/S0950268821000224 Text en © The Author(s) 2021 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Pett, J.
McAleavey, P.
McGurnaghan, P.
Spiers, R.
O'Doherty, M.
Patterson, L.
Johnston, J.
Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020
title Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020
title_full Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020
title_fullStr Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020
title_full_unstemmed Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020
title_short Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020
title_sort epidemiology of covid-19 in northern ireland, 26 february 2020–26 april 2020
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873460/
https://www.ncbi.nlm.nih.gov/pubmed/33509318
http://dx.doi.org/10.1017/S0950268821000224
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