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Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma

The prognostic value of albumin changes between diagnosis and end-of-treatment (EoT) in diffuse large B-cell lymphoma (DLBCL) remains unknown. We retrospectively analyzed 574 de novo DLBCL patients treated with R-CHOP from our and two other centers. All patients were divided into a training cohort (...

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Autores principales: Wei, Xiaolei, Zheng, Jingxia, Zhang, Zewen, Liu, Qiongzhi, Zhan, Minglang, Huang, Weimin, Chen, Junjie, Wei, Qi, Wei, Yongqiang, Feng, Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873605/
https://www.ncbi.nlm.nih.gov/pubmed/33585232
http://dx.doi.org/10.3389/fonc.2020.610681
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author Wei, Xiaolei
Zheng, Jingxia
Zhang, Zewen
Liu, Qiongzhi
Zhan, Minglang
Huang, Weimin
Chen, Junjie
Wei, Qi
Wei, Yongqiang
Feng, Ru
author_facet Wei, Xiaolei
Zheng, Jingxia
Zhang, Zewen
Liu, Qiongzhi
Zhan, Minglang
Huang, Weimin
Chen, Junjie
Wei, Qi
Wei, Yongqiang
Feng, Ru
author_sort Wei, Xiaolei
collection PubMed
description The prognostic value of albumin changes between diagnosis and end-of-treatment (EoT) in diffuse large B-cell lymphoma (DLBCL) remains unknown. We retrospectively analyzed 574 de novo DLBCL patients treated with R-CHOP from our and two other centers. All patients were divided into a training cohort (n = 278) and validation cohort (n = 296) depending on the source of the patients. Overall survival (OS) and progression-free survival (PFS) were analyzed by the method of Kaplan–Meier and Cox proportional hazard regression model. In the training cohort, 163 (58.6%) patients had low serum albumin at diagnosis, and 80 of them were present with consecutive hypoalbuminemia at EoT. Patients with consecutive hypoalbuminemia showed inferior OS and PFS (p = 0.010 and p = 0.079, respectively). Similar survival differences were also observed in the independent validation cohort (p = 0.006 and p = 0.030, respectively). Multivariable analysis revealed that consecutive hypoalbuminemia was an independent prognostic factor OS [relative risk (RR), 2.249; 95% confidence interval (CI), 1.441–3.509, p < 0.001] and PFS (RR, 2.001; 95% CI, 1.443–2.773, p < 0.001) in all DLBCL patients independent of IPI. In conclusion, consecutive hypoalbuminemia is a simple and effective adverse prognostic factor in patients with DLBCL, which reminds us to pay more attention to patients with low serum albumin at EoT during follow-up.
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spelling pubmed-78736052021-02-11 Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma Wei, Xiaolei Zheng, Jingxia Zhang, Zewen Liu, Qiongzhi Zhan, Minglang Huang, Weimin Chen, Junjie Wei, Qi Wei, Yongqiang Feng, Ru Front Oncol Oncology The prognostic value of albumin changes between diagnosis and end-of-treatment (EoT) in diffuse large B-cell lymphoma (DLBCL) remains unknown. We retrospectively analyzed 574 de novo DLBCL patients treated with R-CHOP from our and two other centers. All patients were divided into a training cohort (n = 278) and validation cohort (n = 296) depending on the source of the patients. Overall survival (OS) and progression-free survival (PFS) were analyzed by the method of Kaplan–Meier and Cox proportional hazard regression model. In the training cohort, 163 (58.6%) patients had low serum albumin at diagnosis, and 80 of them were present with consecutive hypoalbuminemia at EoT. Patients with consecutive hypoalbuminemia showed inferior OS and PFS (p = 0.010 and p = 0.079, respectively). Similar survival differences were also observed in the independent validation cohort (p = 0.006 and p = 0.030, respectively). Multivariable analysis revealed that consecutive hypoalbuminemia was an independent prognostic factor OS [relative risk (RR), 2.249; 95% confidence interval (CI), 1.441–3.509, p < 0.001] and PFS (RR, 2.001; 95% CI, 1.443–2.773, p < 0.001) in all DLBCL patients independent of IPI. In conclusion, consecutive hypoalbuminemia is a simple and effective adverse prognostic factor in patients with DLBCL, which reminds us to pay more attention to patients with low serum albumin at EoT during follow-up. Frontiers Media S.A. 2021-01-27 /pmc/articles/PMC7873605/ /pubmed/33585232 http://dx.doi.org/10.3389/fonc.2020.610681 Text en Copyright © 2021 Wei, Zheng, Zhang, Liu, Zhan, Huang, Chen, Wei, Wei and Feng http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wei, Xiaolei
Zheng, Jingxia
Zhang, Zewen
Liu, Qiongzhi
Zhan, Minglang
Huang, Weimin
Chen, Junjie
Wei, Qi
Wei, Yongqiang
Feng, Ru
Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma
title Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma
title_full Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma
title_fullStr Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma
title_full_unstemmed Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma
title_short Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma
title_sort consecutive hypoalbuminemia predicts inferior outcome in patients with diffuse large b-cell lymphoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873605/
https://www.ncbi.nlm.nih.gov/pubmed/33585232
http://dx.doi.org/10.3389/fonc.2020.610681
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