Systemic delivery of human GlyR IgG antibody induces GlyR internalization into motor neurons of brainstem and spinal cord with motor dysfunction in mice

AIMS: Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a life‐threatening condition often associated with highly raised serum antibodies to glycine receptors (GlyRs); these bind to the surface of large neurons and interneurons in rodent brain and spinal cord sections and, in vitro...

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Detalles Bibliográficos
Autores principales: Carvajal‐González, A., Jacobson, L., Clover, L., Wickremaratchi, M., Shields, S., Lang, B., Vincent, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873718/
https://www.ncbi.nlm.nih.gov/pubmed/32910464
http://dx.doi.org/10.1111/nan.12666

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