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A rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report
BACKGROUND: Pheochromocytoma is a rare catecholamine-producing tumour that classically displays clinical manifestations related to alpha-adrenergic stimulation, including paroxysmal or sustained hypertension. However, it may occasionally be complicated by life-threatening crisis, leading to refracto...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873792/ https://www.ncbi.nlm.nih.gov/pubmed/33598609 http://dx.doi.org/10.1093/ehjcr/ytaa513 |
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author | Dominedò, Cristina D’Avino, Emilio Martinotti, Alessandra Cingolani, Emiliano |
author_facet | Dominedò, Cristina D’Avino, Emilio Martinotti, Alessandra Cingolani, Emiliano |
author_sort | Dominedò, Cristina |
collection | PubMed |
description | BACKGROUND: Pheochromocytoma is a rare catecholamine-producing tumour that classically displays clinical manifestations related to alpha-adrenergic stimulation, including paroxysmal or sustained hypertension. However, it may occasionally be complicated by life-threatening crisis, leading to refractory acute heart dysfunction in the most severe cases. CASE SUMMARY: A 28-year-old woman was admitted to intensive care unit due to hypertensive crisis causing pulmonary oedema, Takotsubo cardiomyopathy, and metabolic acidosis. Due to cardiogenic shock, she required venoarterial extracorporeal membrane oxygenation and IMPELLA implantation. A computed tomography scan revealed a 5 cm tumour of the left adrenal gland compatible with pheochromocytoma The clinical course was complicated by acute kidney injury requiring renal replacement therapy and posterior reversible encephalopathy syndrome (PRES). Pharmacological treatment with alpha lityc agents (including urapidil, dexmedetomidine, and doxazosin at maximum daily dose) and beta blockers, together with left videolaparoscopic adrenalectomy, led to progressive blood pressure control and resolution of the neurological symptoms. DISCUSSION: Pheochromocytoma crisis turned into a potential catastrophic scenario, characterized by refractory cardiogenic shock requiring circulatory supportive devices and PRES. Alpha-antagonists and beta-blockers were the gold standard pharmacological treatment. A multidisciplinary decision-algorithm was necessary to successfully manage this complex clinical setting. |
format | Online Article Text |
id | pubmed-7873792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-78737922021-02-16 A rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report Dominedò, Cristina D’Avino, Emilio Martinotti, Alessandra Cingolani, Emiliano Eur Heart J Case Rep Case Report BACKGROUND: Pheochromocytoma is a rare catecholamine-producing tumour that classically displays clinical manifestations related to alpha-adrenergic stimulation, including paroxysmal or sustained hypertension. However, it may occasionally be complicated by life-threatening crisis, leading to refractory acute heart dysfunction in the most severe cases. CASE SUMMARY: A 28-year-old woman was admitted to intensive care unit due to hypertensive crisis causing pulmonary oedema, Takotsubo cardiomyopathy, and metabolic acidosis. Due to cardiogenic shock, she required venoarterial extracorporeal membrane oxygenation and IMPELLA implantation. A computed tomography scan revealed a 5 cm tumour of the left adrenal gland compatible with pheochromocytoma The clinical course was complicated by acute kidney injury requiring renal replacement therapy and posterior reversible encephalopathy syndrome (PRES). Pharmacological treatment with alpha lityc agents (including urapidil, dexmedetomidine, and doxazosin at maximum daily dose) and beta blockers, together with left videolaparoscopic adrenalectomy, led to progressive blood pressure control and resolution of the neurological symptoms. DISCUSSION: Pheochromocytoma crisis turned into a potential catastrophic scenario, characterized by refractory cardiogenic shock requiring circulatory supportive devices and PRES. Alpha-antagonists and beta-blockers were the gold standard pharmacological treatment. A multidisciplinary decision-algorithm was necessary to successfully manage this complex clinical setting. Oxford University Press 2021-01-12 /pmc/articles/PMC7873792/ /pubmed/33598609 http://dx.doi.org/10.1093/ehjcr/ytaa513 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Report Dominedò, Cristina D’Avino, Emilio Martinotti, Alessandra Cingolani, Emiliano A rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report |
title | A rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report |
title_full | A rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report |
title_fullStr | A rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report |
title_full_unstemmed | A rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report |
title_short | A rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report |
title_sort | rare pheochromocytoma complicated by cardiogenic shock and posterior reversible encephalopathy syndrome: case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873792/ https://www.ncbi.nlm.nih.gov/pubmed/33598609 http://dx.doi.org/10.1093/ehjcr/ytaa513 |
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