Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell lineages: a classical lineage of activated and resting m...

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Detalles Bibliográficos
Autores principales: Sutton, Henry J., Aye, Racheal, Idris, Azza H., Vistein, Rachel, Nduati, Eunice, Kai, Oscar, Mwacharo, Jedida, Li, Xi, Gao, Xin, Andrews, T. Daniel, Koutsakos, Marios, Nguyen, Thi H.O., Nekrasov, Maxim, Milburn, Peter, Eltahla, Auda, Berry, Andrea A., KC, Natasha, Chakravarty, Sumana, Sim, B. Kim Lee, Wheatley, Adam K., Kent, Stephen J., Hoffman, Stephen L., Lyke, Kirsten E., Bejon, Philip, Luciani, Fabio, Kedzierska, Katherine, Seder, Robert A., Ndungu, Francis M., Cockburn, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873835/
https://www.ncbi.nlm.nih.gov/pubmed/33567273
http://dx.doi.org/10.1016/j.celrep.2020.108684

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