H3 Relaxin Alleviates Migration, Apoptosis and Pyroptosis Through P2X7R-Mediated Nucleotide Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation in Retinopathy Induced by Hyperglycemia

Introduction: P2X7R excitation-interrelated NLRP3 inflammasome activation induced by high glucose contributes to the pathogenesis of diabetic retinopathy (DR). Relaxin-3 is a bioactive peptide with a structure similar to insulin, which has been reported to be effective in diabetic cardiomyopathy mod...

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Detalles Bibliográficos
Autores principales: Yang, Kelaier, Liu, Jiannan, Zhang, Xiaohui, Ren, Ziqi, Gao, Lei, Wang, Ying, Lin, Wenjian, Ma, Xuefei, Hao, Ming, Kuang, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873867/
https://www.ncbi.nlm.nih.gov/pubmed/33584279
http://dx.doi.org/10.3389/fphar.2020.603689

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