Study on Isomeric Impurities in Cefotiam Hydrochloride

In this study, two isomeric impurities were identified in cefotiam hydrochloride injection preparation and were characterized. Column-switching HPLC-MS and NMR techniques were used to identify the impurity 1 as the Δ3(4) isomers of cefotiam. Using software-based calculations, it was predicted that n...

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Autores principales: Tian, Ye, Chong, Xiao-Meng, Liu, Ying, Han, Ying, Hu, Chang-Qin, Yao, Shang-chen, Xu, Ming-Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873999/
https://www.ncbi.nlm.nih.gov/pubmed/33585401
http://dx.doi.org/10.3389/fchem.2020.619307
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author Tian, Ye
Chong, Xiao-Meng
Liu, Ying
Han, Ying
Hu, Chang-Qin
Yao, Shang-chen
Xu, Ming-Zhe
author_facet Tian, Ye
Chong, Xiao-Meng
Liu, Ying
Han, Ying
Hu, Chang-Qin
Yao, Shang-chen
Xu, Ming-Zhe
author_sort Tian, Ye
collection PubMed
description In this study, two isomeric impurities were identified in cefotiam hydrochloride injection preparation and were characterized. Column-switching HPLC-MS and NMR techniques were used to identify the impurity 1 as the Δ3(4) isomers of cefotiam. Using software-based calculations, it was predicted that neither of the isomeric impurities was embryotoxic. This study provides a reference for the production, storage, and quality control of cefotiam and related cephalosporin antibiotics.
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spelling pubmed-78739992021-02-11 Study on Isomeric Impurities in Cefotiam Hydrochloride Tian, Ye Chong, Xiao-Meng Liu, Ying Han, Ying Hu, Chang-Qin Yao, Shang-chen Xu, Ming-Zhe Front Chem Chemistry In this study, two isomeric impurities were identified in cefotiam hydrochloride injection preparation and were characterized. Column-switching HPLC-MS and NMR techniques were used to identify the impurity 1 as the Δ3(4) isomers of cefotiam. Using software-based calculations, it was predicted that neither of the isomeric impurities was embryotoxic. This study provides a reference for the production, storage, and quality control of cefotiam and related cephalosporin antibiotics. Frontiers Media S.A. 2021-01-15 /pmc/articles/PMC7873999/ /pubmed/33585401 http://dx.doi.org/10.3389/fchem.2020.619307 Text en Copyright © 2021 Tian, Chong, Liu, Han, Hu, Yao and Xu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Tian, Ye
Chong, Xiao-Meng
Liu, Ying
Han, Ying
Hu, Chang-Qin
Yao, Shang-chen
Xu, Ming-Zhe
Study on Isomeric Impurities in Cefotiam Hydrochloride
title Study on Isomeric Impurities in Cefotiam Hydrochloride
title_full Study on Isomeric Impurities in Cefotiam Hydrochloride
title_fullStr Study on Isomeric Impurities in Cefotiam Hydrochloride
title_full_unstemmed Study on Isomeric Impurities in Cefotiam Hydrochloride
title_short Study on Isomeric Impurities in Cefotiam Hydrochloride
title_sort study on isomeric impurities in cefotiam hydrochloride
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873999/
https://www.ncbi.nlm.nih.gov/pubmed/33585401
http://dx.doi.org/10.3389/fchem.2020.619307
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