SOCS3 Negatively Regulates Cardiac Hypertrophy via Targeting GRP78-Mediated ER Stress During Pressure Overload

Pressure overload-induced hypertrophic remodeling is a critical pathological process leading to heart failure (HF). Suppressor of cytokine signaling-3 (SOCS3) has been demonstrated to protect against cardiac hypertrophy and dysfunction, but its mechanisms are largely unknown. Using primary cardiomyo...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Sun, Wen-Chang, Zhang, Yun-Long, Lin, Qiu-Yue, Liao, Jia-Wei, Song, Gui-Rong, Ma, Xiao-Lei, Li, Hui-Hua, Zhang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874011/
https://www.ncbi.nlm.nih.gov/pubmed/33585485
http://dx.doi.org/10.3389/fcell.2021.629932

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