Promoter Methylation Leads to Decreased ZFP36 Expression and Deregulated NLRP3 Inflammasome Activation in Psoriatic Fibroblasts

The mRNA-destabilizing protein tristetraprolin (TTP), encoded by the ZFP36 gene, is known to be able to end inflammatory responses by directly targeting and destabilizing mRNAs encoding pro-inflammatory cytokines. We analyzed its role in psoriasis, a disease characterized by chronic inflammation. We...

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Detalles Bibliográficos
Autores principales: Bertesi, Matteo, Fantini, Sebastian, Alecci, Claudia, Lotti, Roberta, Martello, Andrea, Parenti, Sandra, Carretta, Chiara, Marconi, Alessandra, Grande, Alexis, Pincelli, Carlo, Zanocco-Marani, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874095/
https://www.ncbi.nlm.nih.gov/pubmed/33585499
http://dx.doi.org/10.3389/fmed.2020.579383

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