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ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role

Most recent studies have stressed a high risk of thromboembolism in patients with SARS-CoV-2 infection, particularly in those with severe COVID-19 pneumonia. Counterbalance between angiotensin-converting-enzyme (ACE) and ACE2 activities in COVID-19 disease may be crucially involved in the thrombo-in...

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Autores principales: Calabrese, Cecilia, Annunziata, Anna, Coppola, Antonietta, Pafundi, Pia Clara, Guarino, Salvatore, Di Spirito, Valentina, Maddaloni, Valeria, Pepe, Nicola, Fiorentino, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874110/
https://www.ncbi.nlm.nih.gov/pubmed/33585520
http://dx.doi.org/10.3389/fmed.2020.631148
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author Calabrese, Cecilia
Annunziata, Anna
Coppola, Antonietta
Pafundi, Pia Clara
Guarino, Salvatore
Di Spirito, Valentina
Maddaloni, Valeria
Pepe, Nicola
Fiorentino, Giuseppe
author_facet Calabrese, Cecilia
Annunziata, Anna
Coppola, Antonietta
Pafundi, Pia Clara
Guarino, Salvatore
Di Spirito, Valentina
Maddaloni, Valeria
Pepe, Nicola
Fiorentino, Giuseppe
author_sort Calabrese, Cecilia
collection PubMed
description Most recent studies have stressed a high risk of thromboembolism in patients with SARS-CoV-2 infection, particularly in those with severe COVID-19 pneumonia. Counterbalance between angiotensin-converting-enzyme (ACE) and ACE2 activities in COVID-19 disease may be crucially involved in the thrombo-inflammatory process. Currently, no study has investigated ACE I/D polymorphism involvement in COVID-19 disease complicated by pulmonary embolism, hence the aim of the present pilot study. This is a retrospective, single-center observational case-control study, conducted at the Sub-Intensive Care Unit of A.O.R.N. Ospedali dei Colli, Cotugno Hospital, Naples (Italy). We included 68 subjects with severe/critical COVID-19 pneumonia. COVID-19 patients were divided according to occurrence of PE (PE+, n = 25) or absence of thromboembolic complications (PE−, n = 43). Assessment of ACE I/D polymorphisms showed a statistically significant difference between PE+ and PE− patients (p = 0.029). Particularly, prevalence of D/D homozygous polymorphism was significantly higher in PE+ COVID-19 patients than in PE− (72 vs. 46.5%; p = 0.048), while heterozygote I/D polymorphism was significantly lower expressed in PE+ patients than in PE− (16 vs. 48.8%; p = 0.009). Computed tomographic pulmonary angiography showed predominantly mono/bilateral sub-segmental embolisms. In conclusion, our findings let us hypothesize a genetic susceptibility to thromboembolism in COVID-19 disease. ACE D/D polymorphism might represent a genetic risk factor, although studies on larger populations are needed.
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spelling pubmed-78741102021-02-11 ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role Calabrese, Cecilia Annunziata, Anna Coppola, Antonietta Pafundi, Pia Clara Guarino, Salvatore Di Spirito, Valentina Maddaloni, Valeria Pepe, Nicola Fiorentino, Giuseppe Front Med (Lausanne) Medicine Most recent studies have stressed a high risk of thromboembolism in patients with SARS-CoV-2 infection, particularly in those with severe COVID-19 pneumonia. Counterbalance between angiotensin-converting-enzyme (ACE) and ACE2 activities in COVID-19 disease may be crucially involved in the thrombo-inflammatory process. Currently, no study has investigated ACE I/D polymorphism involvement in COVID-19 disease complicated by pulmonary embolism, hence the aim of the present pilot study. This is a retrospective, single-center observational case-control study, conducted at the Sub-Intensive Care Unit of A.O.R.N. Ospedali dei Colli, Cotugno Hospital, Naples (Italy). We included 68 subjects with severe/critical COVID-19 pneumonia. COVID-19 patients were divided according to occurrence of PE (PE+, n = 25) or absence of thromboembolic complications (PE−, n = 43). Assessment of ACE I/D polymorphisms showed a statistically significant difference between PE+ and PE− patients (p = 0.029). Particularly, prevalence of D/D homozygous polymorphism was significantly higher in PE+ COVID-19 patients than in PE− (72 vs. 46.5%; p = 0.048), while heterozygote I/D polymorphism was significantly lower expressed in PE+ patients than in PE− (16 vs. 48.8%; p = 0.009). Computed tomographic pulmonary angiography showed predominantly mono/bilateral sub-segmental embolisms. In conclusion, our findings let us hypothesize a genetic susceptibility to thromboembolism in COVID-19 disease. ACE D/D polymorphism might represent a genetic risk factor, although studies on larger populations are needed. Frontiers Media S.A. 2021-01-21 /pmc/articles/PMC7874110/ /pubmed/33585520 http://dx.doi.org/10.3389/fmed.2020.631148 Text en Copyright © 2021 Calabrese, Annunziata, Coppola, Pafundi, Guarino, Di Spirito, Maddaloni, Pepe and Fiorentino. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Calabrese, Cecilia
Annunziata, Anna
Coppola, Antonietta
Pafundi, Pia Clara
Guarino, Salvatore
Di Spirito, Valentina
Maddaloni, Valeria
Pepe, Nicola
Fiorentino, Giuseppe
ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role
title ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role
title_full ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role
title_fullStr ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role
title_full_unstemmed ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role
title_short ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role
title_sort ace gene i/d polymorphism and acute pulmonary embolism in covid19 pneumonia: a potential predisposing role
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874110/
https://www.ncbi.nlm.nih.gov/pubmed/33585520
http://dx.doi.org/10.3389/fmed.2020.631148
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