Research Progress of Sirtuin4 in Cancer

Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located ma...

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Detalles Bibliográficos
Autores principales: Bai, Yibing, Yang, Jiani, Cui, Ying, Yao, Yuanfei, Wu, Feng, Liu, Caiqi, Fan, Xiaona, Zhang, Yanqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874138/
https://www.ncbi.nlm.nih.gov/pubmed/33585187
http://dx.doi.org/10.3389/fonc.2020.562950
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author Bai, Yibing
Yang, Jiani
Cui, Ying
Yao, Yuanfei
Wu, Feng
Liu, Caiqi
Fan, Xiaona
Zhang, Yanqiao
author_facet Bai, Yibing
Yang, Jiani
Cui, Ying
Yao, Yuanfei
Wu, Feng
Liu, Caiqi
Fan, Xiaona
Zhang, Yanqiao
author_sort Bai, Yibing
collection PubMed
description Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms.
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spelling pubmed-78741382021-02-11 Research Progress of Sirtuin4 in Cancer Bai, Yibing Yang, Jiani Cui, Ying Yao, Yuanfei Wu, Feng Liu, Caiqi Fan, Xiaona Zhang, Yanqiao Front Oncol Oncology Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a conserved family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases. SIRTS are involved in intricate cellular processes. There are seven subtypes of SIRTs (1–7) in mammals. SIRT4 is located mainly in mitochondria and has various catalytic activities. These enzyme activities give it a diverse range of important biologic functions, such as energy metabolism, oxidative stress, and aging. Cancer is characterized as reprogramming of energy metabolism and redox imbalance, and SIRT4 can affect tumorigenesis. Here, we review the structure, localization, and enzyme activity of SIRT4 and its role in various neoplasms. Frontiers Media S.A. 2021-01-08 /pmc/articles/PMC7874138/ /pubmed/33585187 http://dx.doi.org/10.3389/fonc.2020.562950 Text en Copyright © 2021 Bai, Yang, Cui, Yao, Wu, Liu, Fan and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bai, Yibing
Yang, Jiani
Cui, Ying
Yao, Yuanfei
Wu, Feng
Liu, Caiqi
Fan, Xiaona
Zhang, Yanqiao
Research Progress of Sirtuin4 in Cancer
title Research Progress of Sirtuin4 in Cancer
title_full Research Progress of Sirtuin4 in Cancer
title_fullStr Research Progress of Sirtuin4 in Cancer
title_full_unstemmed Research Progress of Sirtuin4 in Cancer
title_short Research Progress of Sirtuin4 in Cancer
title_sort research progress of sirtuin4 in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874138/
https://www.ncbi.nlm.nih.gov/pubmed/33585187
http://dx.doi.org/10.3389/fonc.2020.562950
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