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Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease
Neuropsychiatric symptoms (NPS) are common in Parkinson's disease (PD) and have demonstrated an association with the p. Val66Met, a polymorphism in the BDNF gene. Mild behavioral impairment (MBI) is a validated syndrome describing emergent and persistent NPS in older adults as a marker of poten...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874164/ https://www.ncbi.nlm.nih.gov/pubmed/33584494 http://dx.doi.org/10.3389/fneur.2020.587992 |
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author | Ramezani, Mehrafarin Ruskey, Jennifer A. Martens, Kristina Kibreab, Mekale Javer, Zainul Kathol, Iris Hammer, Tracy Cheetham, Jenelle Leveille, Etienne Martino, Davide Sarna, Justyna R. Gan-Or, Ziv Pfeffer, Gerald Ismail, Zahinoor Monchi, Oury |
author_facet | Ramezani, Mehrafarin Ruskey, Jennifer A. Martens, Kristina Kibreab, Mekale Javer, Zainul Kathol, Iris Hammer, Tracy Cheetham, Jenelle Leveille, Etienne Martino, Davide Sarna, Justyna R. Gan-Or, Ziv Pfeffer, Gerald Ismail, Zahinoor Monchi, Oury |
author_sort | Ramezani, Mehrafarin |
collection | PubMed |
description | Neuropsychiatric symptoms (NPS) are common in Parkinson's disease (PD) and have demonstrated an association with the p. Val66Met, a polymorphism in the BDNF gene. Mild behavioral impairment (MBI) is a validated syndrome describing emergent and persistent NPS in older adults as a marker of potential cognitive decline and dementia. This study investigated if PD patients with the Met allele were more likely to have MBI and whether they had impairments in specific domains of MBI using the Mild Behavioral Impairment Checklist (MBI-C) as the MBI ascertainment tool. One hundred forty-six PD patients were screened for neuropsychiatric and cognitive impairments with the MBI-C and the Montreal Cognitive Assessment (MoCA). All participants were genotyped for the BDNF p.Val66Met single-nucleotide polymorphism (SNP) using TaqMan Genotyping Assay. Statistical analysis was performed using multiple linear and logistic regression models. Met carriers had a 2 times higher likelihood of being MBI positive (MBI-C total score ≥8) than Val carriers. Met carriers had significantly higher MBI-C total scores and significantly greater impairments in the mood/anxiety and the psychotic domains of MBI-C compared to Val carriers. These findings indicate that the BDNF Met allele is associated with a higher neuropsychiatric burden in PD. |
format | Online Article Text |
id | pubmed-7874164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78741642021-02-11 Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease Ramezani, Mehrafarin Ruskey, Jennifer A. Martens, Kristina Kibreab, Mekale Javer, Zainul Kathol, Iris Hammer, Tracy Cheetham, Jenelle Leveille, Etienne Martino, Davide Sarna, Justyna R. Gan-Or, Ziv Pfeffer, Gerald Ismail, Zahinoor Monchi, Oury Front Neurol Neurology Neuropsychiatric symptoms (NPS) are common in Parkinson's disease (PD) and have demonstrated an association with the p. Val66Met, a polymorphism in the BDNF gene. Mild behavioral impairment (MBI) is a validated syndrome describing emergent and persistent NPS in older adults as a marker of potential cognitive decline and dementia. This study investigated if PD patients with the Met allele were more likely to have MBI and whether they had impairments in specific domains of MBI using the Mild Behavioral Impairment Checklist (MBI-C) as the MBI ascertainment tool. One hundred forty-six PD patients were screened for neuropsychiatric and cognitive impairments with the MBI-C and the Montreal Cognitive Assessment (MoCA). All participants were genotyped for the BDNF p.Val66Met single-nucleotide polymorphism (SNP) using TaqMan Genotyping Assay. Statistical analysis was performed using multiple linear and logistic regression models. Met carriers had a 2 times higher likelihood of being MBI positive (MBI-C total score ≥8) than Val carriers. Met carriers had significantly higher MBI-C total scores and significantly greater impairments in the mood/anxiety and the psychotic domains of MBI-C compared to Val carriers. These findings indicate that the BDNF Met allele is associated with a higher neuropsychiatric burden in PD. Frontiers Media S.A. 2021-01-14 /pmc/articles/PMC7874164/ /pubmed/33584494 http://dx.doi.org/10.3389/fneur.2020.587992 Text en Copyright © 2021 Ramezani, Ruskey, Martens, Kibreab, Javer, Kathol, Hammer, Cheetham, Leveille, Martino, Sarna, Gan-Or, Pfeffer, Ismail and Monchi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Ramezani, Mehrafarin Ruskey, Jennifer A. Martens, Kristina Kibreab, Mekale Javer, Zainul Kathol, Iris Hammer, Tracy Cheetham, Jenelle Leveille, Etienne Martino, Davide Sarna, Justyna R. Gan-Or, Ziv Pfeffer, Gerald Ismail, Zahinoor Monchi, Oury Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease |
title | Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease |
title_full | Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease |
title_fullStr | Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease |
title_full_unstemmed | Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease |
title_short | Association Between BDNF Val66Met Polymorphism and Mild Behavioral Impairment in Patients With Parkinson's Disease |
title_sort | association between bdnf val66met polymorphism and mild behavioral impairment in patients with parkinson's disease |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874164/ https://www.ncbi.nlm.nih.gov/pubmed/33584494 http://dx.doi.org/10.3389/fneur.2020.587992 |
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