Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

The antipsychotic drug olanzapine is associated with serious obesity side effects. Hypothalamic astrocytes and associated toll-like receptor-4 (TLR4) signaling play an essential role in obesity pathogenesis. This study investigated the effect of olanzapine on astrocytes and TLR4 signaling both in vi...

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Detalles Bibliográficos
Autores principales: He, Meng, Qian, Kun, Zhang, Ying, Huang, Xu-Feng, Deng, Chao, Zhang, Baohua, Gao, Guanbin, Li, Jing, Xie, Hao, Sun, Taolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874166/
https://www.ncbi.nlm.nih.gov/pubmed/33584172
http://dx.doi.org/10.3389/fnins.2020.589650

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