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Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation

Ischemic cerebral infarction represents a significant cause of disability and death worldwide. Caspase-1 is activated by the NLRP3/ASC pathway and inflammasomes, thus triggering pyroptosis, a programmed cell death. In particular, this death is mediated by gasdermin D (GSDMD), which induces secretion...

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Detalles Bibliográficos
Autores principales:	Liang, Yubin, Song, Pingping, Chen, Wei, Xie, Xuemin, Luo, Rixin, Su, Jiehua, Zhu, Yunhui, Xu, Jiamin, Liu, Rongrong, Zhu, Peizhi, Zhang, Yusheng, Huang, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874210/ https://www.ncbi.nlm.nih.gov/pubmed/33584203 http://dx.doi.org/10.3389/fncel.2020.540669

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