Cargando…

Buformin suppresses osteosarcoma via targeting AMPK signaling pathway

BACKGROUND: Buformin has been reported to be a powerful anticancer drug by activating the AMPK signal. Herein, we aimed to investigate the effects of buformin on osteosarcoma. MATERIAL AND METHODS: Cellular proliferative abilities were determined by cell counting kit-8 and colony formation assays. C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Yan, Lv, Shiqiao, Li, Guangrun, Cui, Jinpeng, Chen, Yunzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2020
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874575/ https://www.ncbi.nlm.nih.gov/pubmed/33817229 http://dx.doi.org/10.1515/biol-2020-0041

Ejemplares similares

Ascorbate Plus Buformin in AML: A Metabolic Targeted Treatment
por: Banella, Cristina, et al.
Publicado: (2022)

FXR suppresses colorectal cancer by inhibiting the Wnt/β-catenin pathway via activation of TLE3
por: Dong, Xingchen, et al.
Publicado: (2022)

Microtubule actin crosslinking factor 1 functions as a novel therapeutic target in lung metastasis of osteosarcoma
por: Yang, Chaofei, et al.
Publicado: (2022)

CTGF/CCN2 promotes the proliferation of human osteosarcoma cells via cross-talking with the stromal CXCL12/CXCR4-AKT-αvβ3 signaling axis in tumor microenvironment
por: Zhou, Zhangxu, et al.
Publicado: (2022)

Relationship between Scheuermann disease and symptomatic thoracic spinal stenosis: A retrospective study
por: Ding, Yan, et al.
Publicado: (2021)

TRANSPLANTABLE OSTEOSARCOMAS WITH HIGH LUNG METASTATIC POTENTIAL IN FISCHER 344 RATS
por: Mii, Yoshio, et al.
Publicado: (1988)

Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways
por: Li, Ying, et al.
Publicado: (2023)

Changes in Radiation Sensitivity of Human Osteosarcoma Cells after p53 Introduction
por: Miyakoshi, Junji, et al.
Publicado: (1995)

Sensitive determination of buformin using poly-aminobenzoic acid modified glassy carbon electrode
por: Jin, Gui-Ying, et al.
Publicado: (2012)

Decreased expression of m6A demethylase ALKBH5 in decidua contributes to preeclampsia via m6A-CORIN-HuR pathway
por: Yang, Jieqiong, et al.
Publicado: (2022)

Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway
por: Li, Hong-Bo, et al.
Publicado: (2021)

Loss of the emei tumor suppressor promotes tumorigenesis via the JNK and Hippo pathway
por: Yang, Shuai, et al.
Publicado: (2022)

Rare variants in TULP3 abolish the suppressive effect on sonic hedgehog signaling and contribute to human neural tube defects
por: Kuang, Lele, et al.
Publicado: (2021)

NRF2 participates in the suppressive tumor immune microenvironment of KRAS/KEAP1 co-mutant non-small cell lung cancer by inhibiting the STING pathway
por: Xiaodan, Sun, et al.
Publicado: (2022)

Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway
por: Hou, Jia-Yi, et al.
Publicado: (2022)

Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRγ signaling
por: Jung, Yoon Seok, et al.
Publicado: (2022)

An interleukin 10 Receptor alpha (IL-10RA) variant with a compound heterozygote mutation shows normal IL-10 signaling activity
por: Lv, Jiajia, et al.
Publicado: (2022)

Metabolic changes in cancer cells upon suppression of MYC
por: Anso, Elena, et al.
Publicado: (2013)

MZF1 (Myeloid Zinc Finger 1) activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF (P300/CBP associated factor)
por: Li, Bowen, et al.
Publicado: (2022)

EBV-Mir-BART5-5p targets p53 independent pathway in cytoplasm: Potential role in EBV lymphomagenesis
por: Wang, Wei-Ting, et al.
Publicado: (2022)

OXCT1 regulates NF-κB signaling pathway through β-hydroxybutyrate-mediated ketone body homeostasis in lung cancer
por: Lu, Zhuo, et al.
Publicado: (2022)

DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis
por: Cui, Qiuxia, et al.
Publicado: (2023)

Protective effect of miR378* on doxorubicin‐induced cardiomyocyte injury via calumenin
por: Wang, Yu, et al.
Publicado: (2018)

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway
por: Andrukhova, Olena, et al.
Publicado: (2012)

High glucose promotes macrophage M1 polarization through miR-32/Mef2d/cAMP signaling pathway
por: Chen, Cong, et al.
Publicado: (2023)

β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity
por: Kim, Minsuh, et al.
Publicado: (2022)

ZYX promotes invasion and metastasis of gastric cancer cells via WNK1/SNAI1axis
por: Jiang, Yi, et al.
Publicado: (2023)

Targeting DNA-PKcs promotes anti-tumoral immunity via triggering cytosolic DNA sensing and inducing an inflamed tumor immuno-microenvironment in metastatic triple-negative breast cancer
por: Ma, Chao, et al.
Publicado: (2023)

Promoter Methylation of TSLC1 and Tumor Suppression by Its Gene Product in Human Prostate Cancer
por: Fukuhara, Hiroshi, et al.
Publicado: (2002)

Suppression of Intestinal Polyp Development by Nimesulide, a Selective Cyclooxygenase‐2 Inhibitor, in Min Mice
por: Nakatsugi, Seiichi, et al.
Publicado: (1997)

Fossilization of melanosomes via sulfurization
por: McNamara, Maria E., et al.
Publicado: (2016)

Overexpression of DA41 in v‐Ha‐ras‐3Y1 Cells Causes Growth Suppression
por: Ozaki, Toshinori, et al.
Publicado: (2000)

In situ antigen modification-based target-redirected universal chimeric antigen receptor T (TRUE CAR-T) cell therapy in solid tumors
por: Sun, Zhichen, et al.
Publicado: (2022)

Point Mutation of the neu Gene in Rat Neural Tumor RT4‐AC Cells: Suppression of Tumorigenicity by s‐Myc
por: Lee, Soo‐Yong, et al.
Publicado: (1990)

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response
por: Li, Zhenhai, et al.
Publicado: (2022)

Atriofascicular pathway detection with novel ablation catheter
por: Shakkottai, Padmanabhan, et al.
Publicado: (2016)

Suppression of Human Pancreatic Cancer Growth in BALB/c Nude Mice by Manumycin, a Farnesyl:protein Transferase Inhibitor
por: Ito, Toshio, et al.
Publicado: (1996)

Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter
por: Ohta, Masataka, et al.
Publicado: (1990)

Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses
por: Hu, Yunhui, et al.
Publicado: (2021)

Verteporfin suppresses osteosarcoma progression by targeting the Hippo signaling pathway
por: Yang, Xianliang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9onbamukibrl4goq7ujt4c0u6t