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Progress in research on the role of fibrinogen in lung cancer
Lung cancer is one of the most prevalent malignancies worldwide. Local recurrence and distant metastasis remain the major causes of treatment failure. It has been recognized that the process of tumor growth and metastasis involves multiple interactions between tumor and host. Various biomarkers have...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874584/ https://www.ncbi.nlm.nih.gov/pubmed/33817221 http://dx.doi.org/10.1515/biol-2020-0035 |
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author | Liu, Xing Shi, Bin |
author_facet | Liu, Xing Shi, Bin |
author_sort | Liu, Xing |
collection | PubMed |
description | Lung cancer is one of the most prevalent malignancies worldwide. Local recurrence and distant metastasis remain the major causes of treatment failure. It has been recognized that the process of tumor growth and metastasis involves multiple interactions between tumor and host. Various biomarkers have been used for predicting tumor recurrence, metastasis, and prognosis in patients with lung cancer. However, these biomarkers are still controversial and require further validation. The relationship between malignancy and coagulation system disorders has been explored for more than a century. Fibrinogen is the most abundant plasma coagulation factor synthesized mainly by hepatic cells. Increased plasma fibrinogen levels were observed in various carcinomas such as gastric cancer, colon cancer, and pancreatic cancer. Recent studies have also investigated the role of fibrinogen in patients with lung cancer. This review aimed to address the role of fibrinogen in lung cancer. |
format | Online Article Text |
id | pubmed-7874584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-78745842021-04-01 Progress in research on the role of fibrinogen in lung cancer Liu, Xing Shi, Bin Open Life Sci Mini-Review Article Lung cancer is one of the most prevalent malignancies worldwide. Local recurrence and distant metastasis remain the major causes of treatment failure. It has been recognized that the process of tumor growth and metastasis involves multiple interactions between tumor and host. Various biomarkers have been used for predicting tumor recurrence, metastasis, and prognosis in patients with lung cancer. However, these biomarkers are still controversial and require further validation. The relationship between malignancy and coagulation system disorders has been explored for more than a century. Fibrinogen is the most abundant plasma coagulation factor synthesized mainly by hepatic cells. Increased plasma fibrinogen levels were observed in various carcinomas such as gastric cancer, colon cancer, and pancreatic cancer. Recent studies have also investigated the role of fibrinogen in patients with lung cancer. This review aimed to address the role of fibrinogen in lung cancer. De Gruyter 2020-06-05 /pmc/articles/PMC7874584/ /pubmed/33817221 http://dx.doi.org/10.1515/biol-2020-0035 Text en © 2020 Xing Liu and Bin Shi, published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Mini-Review Article Liu, Xing Shi, Bin Progress in research on the role of fibrinogen in lung cancer |
title | Progress in research on the role of fibrinogen in lung cancer |
title_full | Progress in research on the role of fibrinogen in lung cancer |
title_fullStr | Progress in research on the role of fibrinogen in lung cancer |
title_full_unstemmed | Progress in research on the role of fibrinogen in lung cancer |
title_short | Progress in research on the role of fibrinogen in lung cancer |
title_sort | progress in research on the role of fibrinogen in lung cancer |
topic | Mini-Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874584/ https://www.ncbi.nlm.nih.gov/pubmed/33817221 http://dx.doi.org/10.1515/biol-2020-0035 |
work_keys_str_mv | AT liuxing progressinresearchontheroleoffibrinogeninlungcancer AT shibin progressinresearchontheroleoffibrinogeninlungcancer |