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Research progress on the mechanism of orexin in pain regulation in different brain regions
Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874592/ https://www.ncbi.nlm.nih.gov/pubmed/33817297 http://dx.doi.org/10.1515/biol-2021-0001 |
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author | Kang, Xianhui Tang, Hongli Liu, Yao Yuan, Yan Wang, Mi |
author_facet | Kang, Xianhui Tang, Hongli Liu, Yao Yuan, Yan Wang, Mi |
author_sort | Kang, Xianhui |
collection | PubMed |
description | Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle, and energy metabolism, but also closely associated with various physiological functions, such as cardiovascular control, reproduction, stress, reward, addiction, and the modulation of pain transmission. At present, studies that have been performed both domestically and abroad have confirmed that orexin and its receptors are closely associated with pain regulation. In this article, the research progress on acute pain regulation involving orexin is reviewed. |
format | Online Article Text |
id | pubmed-7874592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-78745922021-04-01 Research progress on the mechanism of orexin in pain regulation in different brain regions Kang, Xianhui Tang, Hongli Liu, Yao Yuan, Yan Wang, Mi Open Life Sci Review Article Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle, and energy metabolism, but also closely associated with various physiological functions, such as cardiovascular control, reproduction, stress, reward, addiction, and the modulation of pain transmission. At present, studies that have been performed both domestically and abroad have confirmed that orexin and its receptors are closely associated with pain regulation. In this article, the research progress on acute pain regulation involving orexin is reviewed. De Gruyter 2021-01-20 /pmc/articles/PMC7874592/ /pubmed/33817297 http://dx.doi.org/10.1515/biol-2021-0001 Text en © 2021 Xianhui Kang et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Review Article Kang, Xianhui Tang, Hongli Liu, Yao Yuan, Yan Wang, Mi Research progress on the mechanism of orexin in pain regulation in different brain regions |
title | Research progress on the mechanism of orexin in pain regulation in different brain regions |
title_full | Research progress on the mechanism of orexin in pain regulation in different brain regions |
title_fullStr | Research progress on the mechanism of orexin in pain regulation in different brain regions |
title_full_unstemmed | Research progress on the mechanism of orexin in pain regulation in different brain regions |
title_short | Research progress on the mechanism of orexin in pain regulation in different brain regions |
title_sort | research progress on the mechanism of orexin in pain regulation in different brain regions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874592/ https://www.ncbi.nlm.nih.gov/pubmed/33817297 http://dx.doi.org/10.1515/biol-2021-0001 |
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