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Hepatoprotective effects of chamazulene against alcohol-induced liver damage by alleviation of oxidative stress in rat models
Liver injury and disease caused by alcohol is a common complication to human health worldwide. Chamazulene is a natural proazulene with antioxidant and anti-inflammatory properties. This study aims to investigate the hepatoprotective effects of chamazulene against ethanol-induced liver injury in rat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874619/ https://www.ncbi.nlm.nih.gov/pubmed/33817213 http://dx.doi.org/10.1515/biol-2020-0026 |
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author | Wang, Xu Dong, Ke Ma, Yujing Jin, Qizhi Yin, Shujun Wang, Shan |
author_facet | Wang, Xu Dong, Ke Ma, Yujing Jin, Qizhi Yin, Shujun Wang, Shan |
author_sort | Wang, Xu |
collection | PubMed |
description | Liver injury and disease caused by alcohol is a common complication to human health worldwide. Chamazulene is a natural proazulene with antioxidant and anti-inflammatory properties. This study aims to investigate the hepatoprotective effects of chamazulene against ethanol-induced liver injury in rat models. Adult Wistar rats were orally treated with 50% v/v ethanol (8–12 mL/kg body weight [b.w.]) for 6 weeks to induce alcoholic liver injury. Chamazulene was administered orally to rats 1 h prior to ethanol administration at the doses of 25 and 50 mg/kg b.w. for 6 weeks. Silymarin, a commercial drug for hepatoprotection, was orally administered (50 mg/kg b.w.) for the positive control group. Chamazulene significantly reduced (p < 0.05) the levels of serum alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde, whereas the levels of antioxidant enzymes (glutathione peroxidase, catalase, and superoxide dismutase) and reduced glutathione were significantly restored (p < 0.05) in contrast to the ethanol model group. The levels of pro-inflammatory cytokines (tumour necrosis factor-α and interleukin-6) were suppressed by chamazulene (p < 0.05) with relevance to ethanol-induced liver injury. Histopathological alterations were convincing in the chamazulene-treated groups, which showed protective effects against alcoholic liver injury. Chamazulene has a significant hepatoprotective effect against ethanol-induced liver injury through alleviation of oxidative stress and prevention of inflammation. |
format | Online Article Text |
id | pubmed-7874619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-78746192021-04-01 Hepatoprotective effects of chamazulene against alcohol-induced liver damage by alleviation of oxidative stress in rat models Wang, Xu Dong, Ke Ma, Yujing Jin, Qizhi Yin, Shujun Wang, Shan Open Life Sci Research Article Liver injury and disease caused by alcohol is a common complication to human health worldwide. Chamazulene is a natural proazulene with antioxidant and anti-inflammatory properties. This study aims to investigate the hepatoprotective effects of chamazulene against ethanol-induced liver injury in rat models. Adult Wistar rats were orally treated with 50% v/v ethanol (8–12 mL/kg body weight [b.w.]) for 6 weeks to induce alcoholic liver injury. Chamazulene was administered orally to rats 1 h prior to ethanol administration at the doses of 25 and 50 mg/kg b.w. for 6 weeks. Silymarin, a commercial drug for hepatoprotection, was orally administered (50 mg/kg b.w.) for the positive control group. Chamazulene significantly reduced (p < 0.05) the levels of serum alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde, whereas the levels of antioxidant enzymes (glutathione peroxidase, catalase, and superoxide dismutase) and reduced glutathione were significantly restored (p < 0.05) in contrast to the ethanol model group. The levels of pro-inflammatory cytokines (tumour necrosis factor-α and interleukin-6) were suppressed by chamazulene (p < 0.05) with relevance to ethanol-induced liver injury. Histopathological alterations were convincing in the chamazulene-treated groups, which showed protective effects against alcoholic liver injury. Chamazulene has a significant hepatoprotective effect against ethanol-induced liver injury through alleviation of oxidative stress and prevention of inflammation. De Gruyter 2020-04-20 /pmc/articles/PMC7874619/ /pubmed/33817213 http://dx.doi.org/10.1515/biol-2020-0026 Text en © 2020 Xu Wang et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Article Wang, Xu Dong, Ke Ma, Yujing Jin, Qizhi Yin, Shujun Wang, Shan Hepatoprotective effects of chamazulene against alcohol-induced liver damage by alleviation of oxidative stress in rat models |
title | Hepatoprotective effects of chamazulene against alcohol-induced liver
damage by alleviation of oxidative stress in rat models |
title_full | Hepatoprotective effects of chamazulene against alcohol-induced liver
damage by alleviation of oxidative stress in rat models |
title_fullStr | Hepatoprotective effects of chamazulene against alcohol-induced liver
damage by alleviation of oxidative stress in rat models |
title_full_unstemmed | Hepatoprotective effects of chamazulene against alcohol-induced liver
damage by alleviation of oxidative stress in rat models |
title_short | Hepatoprotective effects of chamazulene against alcohol-induced liver
damage by alleviation of oxidative stress in rat models |
title_sort | hepatoprotective effects of chamazulene against alcohol-induced liver
damage by alleviation of oxidative stress in rat models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874619/ https://www.ncbi.nlm.nih.gov/pubmed/33817213 http://dx.doi.org/10.1515/biol-2020-0026 |
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