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Optimizing the Formulation for Ginkgolide B Solid Dispersion
The main purpose of our study is to optimize the formulation for Ginkgolide B (GB) solid dispersion in order to improve its dissolution in water. For the preparation of GB solid dispersion, we use a solvent method. The optimized formulation consists of GB : PVPK30 = 1:10, PVPK30 as the carrier, and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874724/ https://www.ncbi.nlm.nih.gov/pubmed/33817091 http://dx.doi.org/10.1515/biol-2018-0031 |
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author | Wu, Xiao Huo, Qing Quan, Qizhe Yang, Xiaofang Yu, Na Wang, Yue |
author_facet | Wu, Xiao Huo, Qing Quan, Qizhe Yang, Xiaofang Yu, Na Wang, Yue |
author_sort | Wu, Xiao |
collection | PubMed |
description | The main purpose of our study is to optimize the formulation for Ginkgolide B (GB) solid dispersion in order to improve its dissolution in water. For the preparation of GB solid dispersion, we use a solvent method. The optimized formulation consists of GB : PVPK30 = 1:10, PVPK30 as the carrier, and ethanol : dichloromethane = 1:1 as the solvent. They were treated ultrasonically for 10 min at 60°C. The results from scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and particle size analysis show that the morphological appearance of GB changed significantly in solid dispersion. The original crystal form of GB no longer existed, but it was uniformly dispersed within PVPK30 in a non-crystalline form. It is probably because the -C=O in GB forms hydrogen bonds with the -OH of PVPK30 or urea; this produces a nice solid dispersion and significantly improves the dissolution of GB in water. When GB is in a solid dispersion system, GB’s dissolution in water could be enhanced from 30% to 80%. Furthermore, it may even be produced as a solid agent. |
format | Online Article Text |
id | pubmed-7874724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-78747242021-04-01 Optimizing the Formulation for Ginkgolide B Solid Dispersion Wu, Xiao Huo, Qing Quan, Qizhe Yang, Xiaofang Yu, Na Wang, Yue Open Life Sci Research Article The main purpose of our study is to optimize the formulation for Ginkgolide B (GB) solid dispersion in order to improve its dissolution in water. For the preparation of GB solid dispersion, we use a solvent method. The optimized formulation consists of GB : PVPK30 = 1:10, PVPK30 as the carrier, and ethanol : dichloromethane = 1:1 as the solvent. They were treated ultrasonically for 10 min at 60°C. The results from scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and particle size analysis show that the morphological appearance of GB changed significantly in solid dispersion. The original crystal form of GB no longer existed, but it was uniformly dispersed within PVPK30 in a non-crystalline form. It is probably because the -C=O in GB forms hydrogen bonds with the -OH of PVPK30 or urea; this produces a nice solid dispersion and significantly improves the dissolution of GB in water. When GB is in a solid dispersion system, GB’s dissolution in water could be enhanced from 30% to 80%. Furthermore, it may even be produced as a solid agent. De Gruyter 2018-08-21 /pmc/articles/PMC7874724/ /pubmed/33817091 http://dx.doi.org/10.1515/biol-2018-0031 Text en © 2018 Xiao Wu et al., published by De Gruyter http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. |
spellingShingle | Research Article Wu, Xiao Huo, Qing Quan, Qizhe Yang, Xiaofang Yu, Na Wang, Yue Optimizing the Formulation for Ginkgolide B Solid Dispersion |
title | Optimizing the Formulation for Ginkgolide B Solid Dispersion |
title_full | Optimizing the Formulation for Ginkgolide B Solid Dispersion |
title_fullStr | Optimizing the Formulation for Ginkgolide B Solid Dispersion |
title_full_unstemmed | Optimizing the Formulation for Ginkgolide B Solid Dispersion |
title_short | Optimizing the Formulation for Ginkgolide B Solid Dispersion |
title_sort | optimizing the formulation for ginkgolide b solid dispersion |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874724/ https://www.ncbi.nlm.nih.gov/pubmed/33817091 http://dx.doi.org/10.1515/biol-2018-0031 |
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