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Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database
OBJECTIVE: To analyze the expression and its clinical significance of the SEC24D gene in breast cancer. METHODS: The dataset of breast cancer were searched in the UALCAN database, and the data obtained were mined and combined with literature analysis. RESULTS: The mRNA expression of the SEC24D gene...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
De Gruyter
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874789/ https://www.ncbi.nlm.nih.gov/pubmed/33817210 http://dx.doi.org/10.1515/biol-2019-0080 |
| Sumario: | OBJECTIVE: To analyze the expression and its clinical significance of the SEC24D gene in breast cancer. METHODS: The dataset of breast cancer were searched in the UALCAN database, and the data obtained were mined and combined with literature analysis. RESULTS: The mRNA expression of the SEC24D gene in breast cancer tissues was significantly higher than that of breast normal tissues from the UALCAN database (P < 0.05). The promoter methylation levels of the SEC24D gene in breast cancer tissues were lower than that of breast normal tissues (P < 0.05). Survival analysis showed that the relapse-free survival of breast cancer patients with a higher expression of SEC24D gene was significantly worse than those patients with a lower expression of SEC24D (P < 0.05). CONCLUSION: The SEC24D gene has a high expression in breast cancer tissues and its expression level was related to the prognosis of breast cancer patients. |
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