Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database

OBJECTIVE: To analyze the expression and its clinical significance of the SEC24D gene in breast cancer. METHODS: The dataset of breast cancer were searched in the UALCAN database, and the data obtained were mined and combined with literature analysis. RESULTS: The mRNA expression of the SEC24D gene...

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Detalles Bibliográficos
Autores principales: Liu, Zhi, Zhou, Jing, Wang, Zhibao, Zhou, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2019
Materias:
Topical Issue on Precision Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874789/
https://www.ncbi.nlm.nih.gov/pubmed/33817210
http://dx.doi.org/10.1515/biol-2019-0080
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author Liu, Zhi
Zhou, Jing
Wang, Zhibao
Zhou, Zhiqiang
author_facet Liu, Zhi
Zhou, Jing
Wang, Zhibao
Zhou, Zhiqiang
author_sort Liu, Zhi
collection PubMed
description OBJECTIVE: To analyze the expression and its clinical significance of the SEC24D gene in breast cancer. METHODS: The dataset of breast cancer were searched in the UALCAN database, and the data obtained were mined and combined with literature analysis. RESULTS: The mRNA expression of the SEC24D gene in breast cancer tissues was significantly higher than that of breast normal tissues from the UALCAN database (P < 0.05). The promoter methylation levels of the SEC24D gene in breast cancer tissues were lower than that of breast normal tissues (P < 0.05). Survival analysis showed that the relapse-free survival of breast cancer patients with a higher expression of SEC24D gene was significantly worse than those patients with a lower expression of SEC24D (P < 0.05). CONCLUSION: The SEC24D gene has a high expression in breast cancer tissues and its expression level was related to the prognosis of breast cancer patients.
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spelling pubmed-78747892021-04-01 Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database Liu, Zhi Zhou, Jing Wang, Zhibao Zhou, Zhiqiang Open Life Sci Topical Issue on Precision Medicine OBJECTIVE: To analyze the expression and its clinical significance of the SEC24D gene in breast cancer. METHODS: The dataset of breast cancer were searched in the UALCAN database, and the data obtained were mined and combined with literature analysis. RESULTS: The mRNA expression of the SEC24D gene in breast cancer tissues was significantly higher than that of breast normal tissues from the UALCAN database (P < 0.05). The promoter methylation levels of the SEC24D gene in breast cancer tissues were lower than that of breast normal tissues (P < 0.05). Survival analysis showed that the relapse-free survival of breast cancer patients with a higher expression of SEC24D gene was significantly worse than those patients with a lower expression of SEC24D (P < 0.05). CONCLUSION: The SEC24D gene has a high expression in breast cancer tissues and its expression level was related to the prognosis of breast cancer patients. De Gruyter 2019-12-31 /pmc/articles/PMC7874789/ /pubmed/33817210 http://dx.doi.org/10.1515/biol-2019-0080 Text en © 2019 Zhi Liu et al. published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 Public License.
spellingShingle Topical Issue on Precision Medicine
Liu, Zhi
Zhou, Jing
Wang, Zhibao
Zhou, Zhiqiang
Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database
title Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database
title_full Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database
title_fullStr Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database
title_full_unstemmed Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database
title_short Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database
title_sort analysis of sec24d gene in breast cancer based on ualcan database
topic Topical Issue on Precision Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874789/
https://www.ncbi.nlm.nih.gov/pubmed/33817210
http://dx.doi.org/10.1515/biol-2019-0080
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AT zhoujing analysisofsec24dgeneinbreastcancerbasedonualcandatabase
AT wangzhibao analysisofsec24dgeneinbreastcancerbasedonualcandatabase
AT zhouzhiqiang analysisofsec24dgeneinbreastcancerbasedonualcandatabase

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