Effects of Huaiqihuang Granules Adjuvant Therapy in Children with Primary Nephrotic Syndrome

OBJECTIVE: This study aims to observe the curative effect of Huaiqihuang Granules adjuvant therapy on primary nephrotic syndrome (PNS). METHODS: A total of 112 children with PNS were randomly divided into three groups, and changes in serum inflammatory cytokines, interleukin, lymphocyte subsets and...

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Detalles Bibliográficos
Autores principales: Zhou, Ping, Xiao, Qiong, Chen, Lan, Zou, Zhi-Jie, Wang, Yu-Qing, Zhu, Lin, Yu, Hai-Yan, Zhao, Cheng-Guang, Wu, Yu-Bin, Du, Xuan-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874814/
https://www.ncbi.nlm.nih.gov/pubmed/33817188
http://dx.doi.org/10.1515/biol-2019-0058
Descripción
Sumario:OBJECTIVE: This study aims to observe the curative effect of Huaiqihuang Granules adjuvant therapy on primary nephrotic syndrome (PNS). METHODS: A total of 112 children with PNS were randomly divided into three groups, and changes in serum inflammatory cytokines, interleukin, lymphocyte subsets and immunoglobulin were observed. RESULTS: Before treatment, IL-18, TNF-α, CD8+ increased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells decreased. After Huaiqihuang Granules treatment, IL-18, TNF-α, CD8+ decreased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells increased. CONCLUSION: Functions of cell immunity and humoral immunity in PNS patients before treatment were suppressed and disordered. Huaiqihuang granules can play a role in immunoregulation, with slight side reactions.

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