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Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis
INTRODUCTION: Systemic sclerosis (SSc) is an autoimmune connective tissue disease with distinguished fibrosis of the skin and internal organs. Vascular damage, immune dysregulation and fibroblasts activation contribute to SSc pathogenesis. Peroxisome proliferator-activated receptor γ (PPAR-γ) can be...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874880/ https://www.ncbi.nlm.nih.gov/pubmed/33603610 http://dx.doi.org/10.5114/ada.2019.84746 |
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author | Żółkiewicz, Jakub Stochmal, Anna Zaremba, Michał Rudnicka, Lidia Czuwara, Joanna |
author_facet | Żółkiewicz, Jakub Stochmal, Anna Zaremba, Michał Rudnicka, Lidia Czuwara, Joanna |
author_sort | Żółkiewicz, Jakub |
collection | PubMed |
description | INTRODUCTION: Systemic sclerosis (SSc) is an autoimmune connective tissue disease with distinguished fibrosis of the skin and internal organs. Vascular damage, immune dysregulation and fibroblasts activation contribute to SSc pathogenesis. Peroxisome proliferator-activated receptor γ (PPAR-γ) can be a link between cell metabolism and fibrosis in SSc due to its anti-fibrotic and immunomodulatory properties. AIM: To measure the serum level of PPAR-γ in SSc patients and correlate it with the SSc subtype, hs-CRP, disease duration, vascular and internal organ involvement. MATERIAL AND METHODS: Twenty-two SSc patients (15 limited SSc, 7 diffuse SSc) matched with healthy controls were analysed. Clinical and laboratory data were collected including specific antibodies, interstitial lung disease, oesophageal involvement, digital pitting scars, disease duration, Raynaud’s phenomenon (RP) and modified Rodnan skin score (mRSS). PPAR-γ levels were analysed by ELISA. Statistical analysis was performed with χ(2), Student’s t-test and Mann-Whitney-U test. Pearson and Spearman correlation analyses were used to establish variables association. The significance threshold was set at p < 0.05. RESULTS: PPAR-γ concentration was elevated in SSc patients in comparison to controls (p = 0.007) with the highest difference for diffuseSSc (p = 0.004) with significantly elevated mRSS. No association between PPAR-γ levels and hs-CRP, internal organ and vascular involvement, disease duration, autoantibodies and RP onset was found. CONCLUSIONS: The present study revealed elevated serum PPAR-γ in SSc patients, in particular those with a diffuse form, presenting highest mRSS and lowest BMI. Whether circulating PPAR-γ originates from atrophic adipose tissue, reperfused vessels or ischemic tissues needs assessing. Also the biological meaning or effect of elevated serum PPAR-γ requires further studies. |
format | Online Article Text |
id | pubmed-7874880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-78748802021-02-17 Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis Żółkiewicz, Jakub Stochmal, Anna Zaremba, Michał Rudnicka, Lidia Czuwara, Joanna Postepy Dermatol Alergol Original Paper INTRODUCTION: Systemic sclerosis (SSc) is an autoimmune connective tissue disease with distinguished fibrosis of the skin and internal organs. Vascular damage, immune dysregulation and fibroblasts activation contribute to SSc pathogenesis. Peroxisome proliferator-activated receptor γ (PPAR-γ) can be a link between cell metabolism and fibrosis in SSc due to its anti-fibrotic and immunomodulatory properties. AIM: To measure the serum level of PPAR-γ in SSc patients and correlate it with the SSc subtype, hs-CRP, disease duration, vascular and internal organ involvement. MATERIAL AND METHODS: Twenty-two SSc patients (15 limited SSc, 7 diffuse SSc) matched with healthy controls were analysed. Clinical and laboratory data were collected including specific antibodies, interstitial lung disease, oesophageal involvement, digital pitting scars, disease duration, Raynaud’s phenomenon (RP) and modified Rodnan skin score (mRSS). PPAR-γ levels were analysed by ELISA. Statistical analysis was performed with χ(2), Student’s t-test and Mann-Whitney-U test. Pearson and Spearman correlation analyses were used to establish variables association. The significance threshold was set at p < 0.05. RESULTS: PPAR-γ concentration was elevated in SSc patients in comparison to controls (p = 0.007) with the highest difference for diffuseSSc (p = 0.004) with significantly elevated mRSS. No association between PPAR-γ levels and hs-CRP, internal organ and vascular involvement, disease duration, autoantibodies and RP onset was found. CONCLUSIONS: The present study revealed elevated serum PPAR-γ in SSc patients, in particular those with a diffuse form, presenting highest mRSS and lowest BMI. Whether circulating PPAR-γ originates from atrophic adipose tissue, reperfused vessels or ischemic tissues needs assessing. Also the biological meaning or effect of elevated serum PPAR-γ requires further studies. Termedia Publishing House 2019-04-26 2020-12 /pmc/articles/PMC7874880/ /pubmed/33603610 http://dx.doi.org/10.5114/ada.2019.84746 Text en Copyright: © 2019 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Żółkiewicz, Jakub Stochmal, Anna Zaremba, Michał Rudnicka, Lidia Czuwara, Joanna Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis |
title | Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis |
title_full | Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis |
title_fullStr | Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis |
title_full_unstemmed | Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis |
title_short | Circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis |
title_sort | circulating peroxisome proliferator-activated receptor γ is elevated in systemic sclerosis |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874880/ https://www.ncbi.nlm.nih.gov/pubmed/33603610 http://dx.doi.org/10.5114/ada.2019.84746 |
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