EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro

COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the e...

Descripción completa

Detalles Bibliográficos
Autores principales: Jang, Minsu, Park, Rackhyun, Park, Yea-In, Cha, Yeo-Eun, Yamamoto, Ayane, Lee, Jin I., Park, Junsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874949/
https://www.ncbi.nlm.nih.gov/pubmed/33588235
http://dx.doi.org/10.1016/j.bbrc.2021.02.016
_version_ 1783649692061532160
author Jang, Minsu
Park, Rackhyun
Park, Yea-In
Cha, Yeo-Eun
Yamamoto, Ayane
Lee, Jin I.
Park, Junsoo
author_facet Jang, Minsu
Park, Rackhyun
Park, Yea-In
Cha, Yeo-Eun
Yamamoto, Ayane
Lee, Jin I.
Park, Junsoo
author_sort Jang, Minsu
collection PubMed
description COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.
format Online
Article
Text
id pubmed-7874949
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-78749492021-02-11 EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro Jang, Minsu Park, Rackhyun Park, Yea-In Cha, Yeo-Eun Yamamoto, Ayane Lee, Jin I. Park, Junsoo Biochem Biophys Res Commun Article COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication. Elsevier Inc. 2021-04-02 2021-02-10 /pmc/articles/PMC7874949/ /pubmed/33588235 http://dx.doi.org/10.1016/j.bbrc.2021.02.016 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jang, Minsu
Park, Rackhyun
Park, Yea-In
Cha, Yeo-Eun
Yamamoto, Ayane
Lee, Jin I.
Park, Junsoo
EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro
title EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro
title_full EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro
title_fullStr EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro
title_full_unstemmed EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro
title_short EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro
title_sort egcg, a green tea polyphenol, inhibits human coronavirus replication in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874949/
https://www.ncbi.nlm.nih.gov/pubmed/33588235
http://dx.doi.org/10.1016/j.bbrc.2021.02.016
work_keys_str_mv AT jangminsu egcgagreenteapolyphenolinhibitshumancoronavirusreplicationinvitro
AT parkrackhyun egcgagreenteapolyphenolinhibitshumancoronavirusreplicationinvitro
AT parkyeain egcgagreenteapolyphenolinhibitshumancoronavirusreplicationinvitro
AT chayeoeun egcgagreenteapolyphenolinhibitshumancoronavirusreplicationinvitro
AT yamamotoayane egcgagreenteapolyphenolinhibitshumancoronavirusreplicationinvitro
AT leejini egcgagreenteapolyphenolinhibitshumancoronavirusreplicationinvitro
AT parkjunsoo egcgagreenteapolyphenolinhibitshumancoronavirusreplicationinvitro

Ejemplares similares