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Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial

BACKGROUND: Health care personnel (HCP) working in outpatient settings routinely interact with patients with acute respiratory illnesses. Absenteeism following symptom development and lack of staff trained to obtain samples limit efforts to identify pathogens among infected HCP. METHODS: The Respira...

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Autores principales: Los, Jenna, Gaydos, Charlotte A., Gibert, Cynthia L., Gorse, Geoffrey J., Lykken, Jacquelyn, Nyquist, Ann-Christine, Price, Connie S., Radonovich, Lewis J., Rattigan, Susan, Reich, Nicholas, Rodriguez-Barradas, Maria, Simberkoff, Michael, Bessesen, Mary, Brown, Alexandria, Cummings, Derek A.T., Perl, Trish M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874979/
https://www.ncbi.nlm.nih.gov/pubmed/33581146
http://dx.doi.org/10.1016/j.ajic.2021.02.001
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author Los, Jenna
Gaydos, Charlotte A.
Gibert, Cynthia L.
Gorse, Geoffrey J.
Lykken, Jacquelyn
Nyquist, Ann-Christine
Price, Connie S.
Radonovich, Lewis J.
Rattigan, Susan
Reich, Nicholas
Rodriguez-Barradas, Maria
Simberkoff, Michael
Bessesen, Mary
Brown, Alexandria
Cummings, Derek A.T.
Perl, Trish M.
author_facet Los, Jenna
Gaydos, Charlotte A.
Gibert, Cynthia L.
Gorse, Geoffrey J.
Lykken, Jacquelyn
Nyquist, Ann-Christine
Price, Connie S.
Radonovich, Lewis J.
Rattigan, Susan
Reich, Nicholas
Rodriguez-Barradas, Maria
Simberkoff, Michael
Bessesen, Mary
Brown, Alexandria
Cummings, Derek A.T.
Perl, Trish M.
author_sort Los, Jenna
collection PubMed
description BACKGROUND: Health care personnel (HCP) working in outpatient settings routinely interact with patients with acute respiratory illnesses. Absenteeism following symptom development and lack of staff trained to obtain samples limit efforts to identify pathogens among infected HCP. METHODS: The Respiratory Protection Effectiveness Clinical Trial assessed respiratory infection incidence among HCP between 2011 and 2015. Research assistants obtained anterior nasal and oropharyngeal swabs from HCP in the workplace following development of respiratory illness symptoms and randomly while asymptomatic. Participants received take-home kits to self-collect swabs when absent from work. Samples mailed to a central laboratory were tested for respiratory viruses by reverse transcription polymerase chain reaction. RESULTS: Among 2,862 participants, 3,467 swabs were obtained from symptomatic participants. Among symptomatic HCP, respiratory virus was detected in 904 of 3,467 (26.1%) samples. Self-collected samples by symptomatic HCP at home had higher rates of viral detection (40.3%) compared to 24% obtained by trained research assistants in the workplace (P < .001). CONCLUSIONS: In this randomized clinical trial, take-home kits were an easily implemented, effective method to self-collect samples by HCP. Other studies have previously shown relative equivalence of self-collected samples to those obtained by trained healthcare workers. Take-home kit self-collection could diminish workforce exposures and decrease the demand for personnel protective equipment worn to protect workers who collect respiratory samples.
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spelling pubmed-78749792021-02-11 Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial Los, Jenna Gaydos, Charlotte A. Gibert, Cynthia L. Gorse, Geoffrey J. Lykken, Jacquelyn Nyquist, Ann-Christine Price, Connie S. Radonovich, Lewis J. Rattigan, Susan Reich, Nicholas Rodriguez-Barradas, Maria Simberkoff, Michael Bessesen, Mary Brown, Alexandria Cummings, Derek A.T. Perl, Trish M. Am J Infect Control Major Article BACKGROUND: Health care personnel (HCP) working in outpatient settings routinely interact with patients with acute respiratory illnesses. Absenteeism following symptom development and lack of staff trained to obtain samples limit efforts to identify pathogens among infected HCP. METHODS: The Respiratory Protection Effectiveness Clinical Trial assessed respiratory infection incidence among HCP between 2011 and 2015. Research assistants obtained anterior nasal and oropharyngeal swabs from HCP in the workplace following development of respiratory illness symptoms and randomly while asymptomatic. Participants received take-home kits to self-collect swabs when absent from work. Samples mailed to a central laboratory were tested for respiratory viruses by reverse transcription polymerase chain reaction. RESULTS: Among 2,862 participants, 3,467 swabs were obtained from symptomatic participants. Among symptomatic HCP, respiratory virus was detected in 904 of 3,467 (26.1%) samples. Self-collected samples by symptomatic HCP at home had higher rates of viral detection (40.3%) compared to 24% obtained by trained research assistants in the workplace (P < .001). CONCLUSIONS: In this randomized clinical trial, take-home kits were an easily implemented, effective method to self-collect samples by HCP. Other studies have previously shown relative equivalence of self-collected samples to those obtained by trained healthcare workers. Take-home kit self-collection could diminish workforce exposures and decrease the demand for personnel protective equipment worn to protect workers who collect respiratory samples. Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. 2021-07 2021-02-10 /pmc/articles/PMC7874979/ /pubmed/33581146 http://dx.doi.org/10.1016/j.ajic.2021.02.001 Text en © 2021 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Major Article
Los, Jenna
Gaydos, Charlotte A.
Gibert, Cynthia L.
Gorse, Geoffrey J.
Lykken, Jacquelyn
Nyquist, Ann-Christine
Price, Connie S.
Radonovich, Lewis J.
Rattigan, Susan
Reich, Nicholas
Rodriguez-Barradas, Maria
Simberkoff, Michael
Bessesen, Mary
Brown, Alexandria
Cummings, Derek A.T.
Perl, Trish M.
Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial
title Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial
title_full Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial
title_fullStr Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial
title_full_unstemmed Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial
title_short Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial
title_sort take-home kits to detect respiratory viruses among healthcare personnel: lessons learned from a cluster randomized clinical trial
topic Major Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874979/
https://www.ncbi.nlm.nih.gov/pubmed/33581146
http://dx.doi.org/10.1016/j.ajic.2021.02.001
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