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Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case

Gastrin-secreting tumors, hypergastrinemia and severe ulcer disease form the trademarks of Zollinger-Ellison syndrome (ZES). We report a case of gastrinoma, in a patient who was misdiagnosed for almost five years. The case emphsizes the the special role of functional imaging in the personalized appr...

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Autores principales: Stolniceanu, Cati Raluca, Grierosu, Irena Cristina, Matovic, Milovan, Stefanescu, Cipriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875036/
https://www.ncbi.nlm.nih.gov/pubmed/33623513
http://dx.doi.org/10.4103/wjnm.WJNM_16_20
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author Stolniceanu, Cati Raluca
Grierosu, Irena Cristina
Matovic, Milovan
Stefanescu, Cipriana
author_facet Stolniceanu, Cati Raluca
Grierosu, Irena Cristina
Matovic, Milovan
Stefanescu, Cipriana
author_sort Stolniceanu, Cati Raluca
collection PubMed
description Gastrin-secreting tumors, hypergastrinemia and severe ulcer disease form the trademarks of Zollinger-Ellison syndrome (ZES). We report a case of gastrinoma, in a patient who was misdiagnosed for almost five years. The case emphsizes the the special role of functional imaging in the personalized approach to the patient with suggestive symptomatology for NETs. Taking into account that in 80 to 100% of cases of gastroenteropancreatic (GEP) NETs are expressing somatostatin receptors, the functional imaging with radiolabeled somatostatin analogues can be used in order to improve its diagnosis, respectively the treatment of GEP NETs. In the approach to the patient with tremendous digestive symptomatology, physicians from different specialties should evaluate NETs specific markers and then insist on structural-functional complementarity, avoiding the waste of time and high cost of repeated structural investigations. The conclusion of our study is that functional imaging is mandatory in the diagnostic algorithm of gastrinoma.
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spelling pubmed-78750362021-02-22 Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case Stolniceanu, Cati Raluca Grierosu, Irena Cristina Matovic, Milovan Stefanescu, Cipriana World J Nucl Med Case Report Gastrin-secreting tumors, hypergastrinemia and severe ulcer disease form the trademarks of Zollinger-Ellison syndrome (ZES). We report a case of gastrinoma, in a patient who was misdiagnosed for almost five years. The case emphsizes the the special role of functional imaging in the personalized approach to the patient with suggestive symptomatology for NETs. Taking into account that in 80 to 100% of cases of gastroenteropancreatic (GEP) NETs are expressing somatostatin receptors, the functional imaging with radiolabeled somatostatin analogues can be used in order to improve its diagnosis, respectively the treatment of GEP NETs. In the approach to the patient with tremendous digestive symptomatology, physicians from different specialties should evaluate NETs specific markers and then insist on structural-functional complementarity, avoiding the waste of time and high cost of repeated structural investigations. The conclusion of our study is that functional imaging is mandatory in the diagnostic algorithm of gastrinoma. Wolters Kluwer - Medknow 2020-08-22 /pmc/articles/PMC7875036/ /pubmed/33623513 http://dx.doi.org/10.4103/wjnm.WJNM_16_20 Text en Copyright: © 2020 World Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Stolniceanu, Cati Raluca
Grierosu, Irena Cristina
Matovic, Milovan
Stefanescu, Cipriana
Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case
title Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case
title_full Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case
title_fullStr Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case
title_full_unstemmed Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case
title_short Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case
title_sort somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875036/
https://www.ncbi.nlm.nih.gov/pubmed/33623513
http://dx.doi.org/10.4103/wjnm.WJNM_16_20
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