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Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study
BACKGROUND: Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors. METHODS: Participants from 3 adult cohorts in the general population in France were invited to participate in...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875161/ https://www.ncbi.nlm.nih.gov/pubmed/33568097 http://dx.doi.org/10.1186/s12879-021-05864-8 |
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author | Carrat, Fabrice Touvier, Mathilde Severi, Gianluca Meyer, Laurence Jusot, Florence Lapidus, Nathanael Rahib, Delphine Lydié, Nathalie Charles, Marie-Aline Ancel, Pierre-Yves Rouquette, Alexandra de Lamballerie, Xavier Zins, Marie Bajos, Nathalie |
author_facet | Carrat, Fabrice Touvier, Mathilde Severi, Gianluca Meyer, Laurence Jusot, Florence Lapidus, Nathanael Rahib, Delphine Lydié, Nathalie Charles, Marie-Aline Ancel, Pierre-Yves Rouquette, Alexandra de Lamballerie, Xavier Zins, Marie Bajos, Nathalie |
author_sort | Carrat, Fabrice |
collection | PubMed |
description | BACKGROUND: Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors. METHODS: Participants from 3 adult cohorts in the general population in France were invited to participate in a survey on COVID-19. The main outcome was COVID-19-Like Symptoms (CLS), defined as a sudden onset of cough, fever, dyspnea, ageusia and/or anosmia, that lasted more than 3 days and occurred during the 17 days before the survey. We used delayed-entry Cox models to identify associated factors. RESULTS: Between April 2, 2020 and May 12, 2020, 279,478 participants were invited, 116,903 validated the questionnaire and 106,848 were included in the analysis. Three thousand thirty-five cases of CLS were reported during 62,099 person-months of follow-up. The cumulative incidences of CLS were 6.2% (95% Confidence Interval (95%CI): 5.7%; 6.6%) on day 15 and 8.8% (95%CI 8.3%; 9.2%) on day 45 of lockdown. The risk of CLS was lower in older age groups and higher in French regions with a high prevalence of SARS-CoV-2 infection, in participants living in cities > 100,000 inhabitants (vs rural areas), when at least one child or adolescent was living in the same household, in overweight or obese people, and in people with chronic respiratory diseases, anxiety or depression or chronic diseases other than diabetes, cancer, hypertension or cardiovascular diseases. CONCLUSION: The incidence of CLS in the general population remained high during the first 2 weeks of lockdown, and decreased significantly thereafter. Modifiable and non-modifiable risk factors were identified. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-05864-8. |
format | Online Article Text |
id | pubmed-7875161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78751612021-02-11 Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study Carrat, Fabrice Touvier, Mathilde Severi, Gianluca Meyer, Laurence Jusot, Florence Lapidus, Nathanael Rahib, Delphine Lydié, Nathalie Charles, Marie-Aline Ancel, Pierre-Yves Rouquette, Alexandra de Lamballerie, Xavier Zins, Marie Bajos, Nathalie BMC Infect Dis Research Article BACKGROUND: Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors. METHODS: Participants from 3 adult cohorts in the general population in France were invited to participate in a survey on COVID-19. The main outcome was COVID-19-Like Symptoms (CLS), defined as a sudden onset of cough, fever, dyspnea, ageusia and/or anosmia, that lasted more than 3 days and occurred during the 17 days before the survey. We used delayed-entry Cox models to identify associated factors. RESULTS: Between April 2, 2020 and May 12, 2020, 279,478 participants were invited, 116,903 validated the questionnaire and 106,848 were included in the analysis. Three thousand thirty-five cases of CLS were reported during 62,099 person-months of follow-up. The cumulative incidences of CLS were 6.2% (95% Confidence Interval (95%CI): 5.7%; 6.6%) on day 15 and 8.8% (95%CI 8.3%; 9.2%) on day 45 of lockdown. The risk of CLS was lower in older age groups and higher in French regions with a high prevalence of SARS-CoV-2 infection, in participants living in cities > 100,000 inhabitants (vs rural areas), when at least one child or adolescent was living in the same household, in overweight or obese people, and in people with chronic respiratory diseases, anxiety or depression or chronic diseases other than diabetes, cancer, hypertension or cardiovascular diseases. CONCLUSION: The incidence of CLS in the general population remained high during the first 2 weeks of lockdown, and decreased significantly thereafter. Modifiable and non-modifiable risk factors were identified. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-05864-8. BioMed Central 2021-02-10 /pmc/articles/PMC7875161/ /pubmed/33568097 http://dx.doi.org/10.1186/s12879-021-05864-8 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Carrat, Fabrice Touvier, Mathilde Severi, Gianluca Meyer, Laurence Jusot, Florence Lapidus, Nathanael Rahib, Delphine Lydié, Nathalie Charles, Marie-Aline Ancel, Pierre-Yves Rouquette, Alexandra de Lamballerie, Xavier Zins, Marie Bajos, Nathalie Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study |
title | Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study |
title_full | Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study |
title_fullStr | Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study |
title_full_unstemmed | Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study |
title_short | Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study |
title_sort | incidence and risk factors of covid-19-like symptoms in the french general population during the lockdown period: a multi-cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875161/ https://www.ncbi.nlm.nih.gov/pubmed/33568097 http://dx.doi.org/10.1186/s12879-021-05864-8 |
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